Department of Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Department of Infectious diseases, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India; Manipal McGill Center for Infectious Diseases, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Infez Med. 2021 Mar 1;29(1):65-69.
The clinical epidemiology of patients with brucellosis in India has not been well described. The aim of this study was therefore to delineate the demographic and clinical characteristics, complications and treatment outcomes of patients diagnosed with brucellosis. A prospective cohort study was conducted from January 2015 to June 2017. All patients above the age of 18 years with a confirmed diagnosis of brucellosis were enrolled and followed up for six months to study the outcomes of treatment. Of the 94 patients enrolled, 77% were male. A total of 38% of the patients had a history of animal contact, and 24% had a history of consumption of unpasteurized dairy products. Acute brucellosis was found in 65% of the patients, and sub-acute presentation was seen in the rest. Fever (94%) and arthralgia (54%) were the most predominant symptoms. The most common focal complication was osteoarticular involvement (34%). Except for three patients, all those who were available for follow-up showed a complete response to therapy. In conclusion, brucellosis should be suspected in patients with fever and osteoarticular involvement in endemic areas. Early identification and prompt initiation of treatment are associated with high cure rates.
印度布鲁氏菌病患者的临床流行病学尚未得到很好的描述。因此，本研究旨在描述诊断为布鲁氏菌病患者的人口统计学和临床特征、并发症和治疗结果。这是一项前瞻性队列研究，于 2015 年 1 月至 2017 年 6 月进行。纳入了所有年龄在 18 岁以上、确诊为布鲁氏菌病的患者，并进行了为期六个月的随访，以研究治疗结果。在纳入的 94 名患者中，77%为男性。共有 38%的患者有动物接触史，24%有食用未经巴氏消毒的乳制品史。65%的患者为急性布鲁氏菌病，其余为亚急性表现。发热（94%）和关节炎（54%）是最常见的症状。最常见的局部并发症是骨关节炎受累（34%）。除了 3 名患者外，所有可进行随访的患者均对治疗有完全反应。总之，在流行地区，对于发热和骨关节炎受累的患者应怀疑布鲁氏菌病。早期识别和及时开始治疗与高治愈率相关。
