Department of Internal Medicine, Kasturba Medical College, Manipal University, Karnataka, India.
Asian Pac J Trop Med. 2011 May;4(5):397-400. doi: 10.1016/S1995-7645(11)60111-9. Epub 2011 Jun 22.
To highlight the spectrum of clinical manifestations, labs, complications, treatment and outcome of brucellosis.
Retrospective study was conducted in Kasturba Medical College, Manipal University, Karnataka, India which included 68 confirmed cases of brucellosis from January 2006- April 2010. Diagnosis of brucellosis was made by culturing the sera/body fluids by standard BACTEC method (or) by testing the sera for Brucella agglutinins using the standard agglutination test (SAT). A titer of 1:320 or more was considered as significant. SPSS 16 was used for statistical analysis and Microsoft Excel for graphical representation.
Of the 68 patients, 46 (68%) were male and 22 (32%) were female patients with age distribution of 9-75 years. Forty four (64.7%) had history of contact with unpasteurized dairy products or infected animals. Symptoms included fever (68, 100%), myalgia (21, 31%), musculoskeletal symptoms (23, 34%), headache (16, 24%), gastrointestinal symptoms (19, 28%) and altered sensorium (3, 4%). Co-morbidities and associations included HIV positivity (2, 3%), type 2 diabetes mellitus (13, 19%), steroid therapy (3, 4%) and HBsAg positivity (8, 12%). Ten (15%) patients had cervical lymphadenopathy, 4(6%) had splenic enlargement, 6 (7%) had hepatomegaly, 19 (28%) had hepatosplenomegaly and 2(3%) got meningeal signs. Anaemia was observed in 39 (57.3%) cases, high erythrocyte sedimentation rate (ESR) was present in 55 (80.8%) cases, leucocytosis in 10(14.7%), leucopenia in 10(14.7%), thrombocytopenia in 23 (33.82%) and thrombocytosis in 2 (2.94%) cases.
In countries like India, where brucellosis and tuberculosis are endemic; rapid, sensitive and highly specific diagnostic methods are required to make early diagnosis and prevent resistance as there is an overlap in therapy.
强调布鲁氏菌病的临床表现、实验室检查、并发症、治疗和预后谱。
本研究为回顾性研究，在印度卡纳塔克邦马纳普尔大学卡斯特巴医学学院进行，纳入了 2006 年 1 月至 2010 年 4 月的 68 例确诊布鲁氏菌病患者。布鲁氏菌病的诊断通过标准 BACTEC 方法培养血清/体液（或）使用标准凝集试验（SAT）检测血清中的布鲁氏菌凝集素来进行。滴度为 1:320 或更高被认为具有显著性。使用 SPSS 16 进行统计分析，使用 Microsoft Excel 进行图形表示。
68 例患者中，男 46 例（68%），女 22 例（32%），年龄 9-75 岁。44 例（64.7%）有接触未经巴氏消毒的乳制品或感染动物的病史。症状包括发热（68 例，100%）、肌痛（21 例，31%）、肌肉骨骼症状（23 例，34%）、头痛（16 例，24%）、胃肠道症状（19 例，28%）和意识改变（3 例，4%）。合并症和关联包括 HIV 阳性（2 例，3%）、2 型糖尿病（13 例，19%）、类固醇治疗（3 例，4%）和 HBsAg 阳性（8 例，12%）。10 例（15%）患者有颈部淋巴结病，4 例（6%）有脾肿大，6 例（7%）有肝肿大，19 例（28%）有肝脾肿大，2 例（3%）有脑膜征。39 例（57.3%）患者存在贫血，55 例（80.8%）患者红细胞沉降率升高，10 例（14.7%）白细胞增多，10 例（14.7%）白细胞减少，23 例（33.82%）血小板减少，2 例（2.94%）血小板增多。
在印度等布鲁氏菌病和结核病流行的国家，需要快速、敏感和高度特异性的诊断方法，以便早期诊断和预防耐药性，因为两者的治疗方法存在重叠。
