Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Italy.
Infez Med. 2021 Mar 1;29(1):123-129.
Bacillus Calmette-Guérin (BCG), a live, attenuated strain of Mycobacterium bovis, is the essential constituent of the vaccine against tuberculosis and the gold-standard adjuvant treatment for urothelial cancer of the bladder. Being a live, attenuated strain with a potential pathogenic action, bacilli can cause several complications, both locally near the inoculation site and remotely through blood dissemination. BCG-related disease can represent a side effect of anti-TB vaccination in patient with congenital or acquired immunodeficiency or a complication of the therapeutic schedule in oncologic patients. Herein we report five cases of BCG-related disease which occurred at the Infectious Diseases Department of the University Hospital of Palermo during a five-year period from January 2014 to December 2019.
卡介苗（BCG）是一株减毒活的牛型分枝杆菌，是预防结核病的疫苗的主要组成部分，也是膀胱尿路上皮癌的金标准辅助治疗药物。作为一株具有潜在致病性的减毒活菌株，卡介苗可以在接种部位局部和通过血液传播导致多种并发症。卡介苗相关疾病可能是先天性或获得性免疫缺陷患者抗结核疫苗接种的副作用，也可能是肿瘤患者治疗方案的并发症。本文报道了 2014 年 1 月至 2019 年 12 月期间在巴勒莫大学医院传染病科发生的 5 例卡介苗相关疾病。
