Ahangarpour Akram, Heidari Hamid, Oroojan Ali Akbar, Mirzavandi Farhang, Nasr Esfehani Khalil, Dehghan Mohammadi Zeinab
Health Research Institute, Diabetes Research Center, Department of Physiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Physiology, Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Department of Physiology, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
Avicenna J Phytomed. 2017 Mar-Apr;7(2):169-179.
(burdock), root has hypoglycemic and antioxidative effects, and has been used for treatment of diabetes in tradition medicine. This study was conducted to evaluate the antidiabetic and hypolipidemic properties of root extract on nicotinamide-streptozotocin (NA-STZ)-induced type2 diabetes in mice.
In this investigation, 70 adult male NMRI mice (30-35g) randomly divided into 7 groups (n=10) as follow: 1-control, 2-type 2 diabetic mice, 3-diabetic mice that received glibenclamide (0.25 mg/kg) as an anti-diabetic drug, 4, 5, 6 and 7- diabetic and normal animals that were pre-treated with 200 and 300 mg/kg root extract, respectively, for 28 days. Diabetes has been induced by intraperitoneal injection of NA and STZ. Finally, the blood sample was taken and insulin, glucose, SGOT, SGPT, alkaline phosphatase, leptin and lipid levels was evaluated.
Induction of diabetes decreased the level of insulin, leptin and high density lipoprotein (HDL) and increased the level of other lipids, glucose, and hepatic enzymes significantly (p<0.05). Administration of both doses of the extract significantly decreased the level of triglyceride, very low density lipoprotein, glucose and alkaline phosphatase in diabetic mice (p<0.05). Insulin levels increased in animals treated with 200 mg/kg (p<0.05) and HDL and leptin levels increased in animals treated with 300 mg/kg of the extract (p<0.01).
The results showed that root extract, at specific doses, has an anti-diabetic effect through its hypolipidemic and insulinotropic properties. Hence, this plant extract may be beneficial in the treatment of diabetes.
牛蒡根具有降血糖和抗氧化作用，在传统医学中已用于治疗糖尿病。本研究旨在评估牛蒡根提取物对烟酰胺 - 链脲佐菌素（NA - STZ）诱导的小鼠2型糖尿病的抗糖尿病和降血脂特性。
在本研究中，70只成年雄性NMRI小鼠（30 - 35克）随机分为7组（n = 10），如下：1 - 对照组，2 - 2型糖尿病小鼠，3 - 接受格列本脲（0.25毫克/千克）作为抗糖尿病药物的糖尿病小鼠，4、5、6和7 - 分别用200和300毫克/千克牛蒡根提取物预处理28天的糖尿病和正常动物。通过腹腔注射NA和STZ诱导糖尿病。最后，采集血样并评估胰岛素、血糖、谷草转氨酶、谷丙转氨酶、碱性磷酸酶、瘦素和血脂水平。
糖尿病诱导显著降低了胰岛素、瘦素和高密度脂蛋白（HDL）水平，并显著增加了其他脂质、血糖和肝酶水平（p < 0.05）。两种剂量的提取物给药均显著降低了糖尿病小鼠的甘油三酯、极低密度脂蛋白、血糖和碱性磷酸酶水平（p < 0.05）。用200毫克/千克提取物处理的动物胰岛素水平升高（p < 0.05），用300毫克/千克提取物处理的动物HDL和瘦素水平升高（p < 0.01）。
结果表明，牛蒡根提取物在特定剂量下通过其降血脂和促胰岛素分泌特性具有抗糖尿病作用。因此，这种植物提取物可能对糖尿病治疗有益。
