D'Souza D, Thomas I M, Das B C
Department of Anatomy, St. John's Medical College, Bangalore, India.
Hum Genet. 1988 May;79(1):83-5. doi: 10.1007/BF00291717.
An unequivocal observation of a higher rate of cellular genetic damage in terms of increased frequencies of sister chromatid exchanges (SCEs) and chromosome aberrations during "ovulatory" and "estrogenic" stages as compared with those of "progestogenic" stage of the menstrual cycle in women and the reported fluctuations in SCEs as a function of time in men indicate that chronobiologic considerations are essential in the design of studies of humans and animals experiments. It seems that female subjects are more influenced by biologic rhythms because of specific hormonal cycles and are sensitive to genetic damage during ovulatory/estrogenic stages of the menstrual cycle.
与女性月经周期的“孕激素期”相比，在“排卵期”和“雌激素期”观察到姐妹染色单体交换（SCEs）频率增加和染色体畸变，从而明确观察到细胞遗传损伤率更高，并且报告显示男性的SCEs随时间波动，这表明时间生物学因素在人类研究和动物实验设计中至关重要。由于特定的激素周期，女性受试者似乎更容易受到生物节律的影响，并且在月经周期的排卵/雌激素期对遗传损伤敏感。
