Chromosomal damage in peripheral blood lymphocytes of patients treated for testicular cancer.
作者信息
van den Berg-de Ruiter E, de Jong B, Mulder N H, te Meerman G J, Schraffordt Koops H, Sleijfer D T
机构信息
Department of Human Genetics, State University, Groninge, The Netherlands.
出版信息
Hum Genet. 1990 Jan;84(2):191-4. doi: 10.1007/BF00208940.
PMID:2298456
Abstract
We describe the presence of a large number of chromosome aberrations in lymphocytes of 50 patients with testicular cancer. These chromosomal aberrations were not only found in patients treated with chemotherapy but also in untreated patients or in patients after surgery alone. Our results suggest a role for genetic instability in the pathogenesis of testicular cancer. This instability might be a risk factor for the development of secondary malignancies.
摘要
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