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Chromosomal damage in peripheral blood lymphocytes of patients treated for testicular cancer.

作者信息

van den Berg-de Ruiter E, de Jong B, Mulder N H, te Meerman G J, Schraffordt Koops H, Sleijfer D T

机构信息

Department of Human Genetics, State University, Groninge, The Netherlands.

出版信息

Hum Genet. 1990 Jan;84(2):191-4. doi: 10.1007/BF00208940.

DOI:10.1007/BF00208940
PMID:2298456
Abstract

We describe the presence of a large number of chromosome aberrations in lymphocytes of 50 patients with testicular cancer. These chromosomal aberrations were not only found in patients treated with chemotherapy but also in untreated patients or in patients after surgery alone. Our results suggest a role for genetic instability in the pathogenesis of testicular cancer. This instability might be a risk factor for the development of secondary malignancies.

摘要

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Chromosomal damage in peripheral blood lymphocytes of patients treated for testicular cancer.
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引用本文的文献

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Cytogenetic studies in lymphocytes of patients with rectal cancer.直肠癌患者淋巴细胞的细胞遗传学研究。
Environ Health Perspect. 1993 Oct;101 Suppl 3(Suppl 3):169-75. doi: 10.1289/ehp.93101s3169.
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Chromosomal damage in lymphocytes and fibroblasts of patients treated for testicular cancer.接受睾丸癌治疗的患者淋巴细胞和成纤维细胞中的染色体损伤。
Hum Genet. 1990 Oct;85(6):675-6. doi: 10.1007/BF00193599.
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Cytogenetic studies of chromosome aberrations.染色体畸变的细胞遗传学研究。

本文引用的文献

1
Occurrence of second tumors in man after anticancer drug treatment.抗癌药物治疗后人类继发性肿瘤的发生情况。
Cancer Treat Rev. 1982 Sep;9(3):167-94. doi: 10.1016/s0305-7372(82)80006-6.
2
Genetic instability in the human population: a working hypothesis.人类群体中的遗传不稳定性：一个可行的假设。
Hereditas. 1983;98(1):1-9. doi: 10.1111/j.1601-5223.1983.tb00574.x.
3
Testicular cancer as a model for a curable neoplasm: The Richard and Hinda Rosenthal Foundation Award Lecture.睾丸癌作为可治愈肿瘤的模型：理查德与欣达·罗森塔尔基金会奖讲座
Hum Genet. 1990 Oct;85(6):672-4. doi: 10.1007/BF00193598.
4
No evidence for constitutional chromosome instability in testicular cancer.睾丸癌中无体质性染色体不稳定的证据。
Hum Genet. 1992 May;89(3):338-40. doi: 10.1007/BF00220554.
Cancer Res. 1981 Sep;41(9 Pt 1):3275-80.
4
Leukemia following treatment of germ cell tumors in men.男性生殖细胞肿瘤治疗后发生的白血病。
J Clin Oncol. 1984 Oct;2(10):1080-7. doi: 10.1200/JCO.1984.2.10.1080.
5
Increased mutation frequency following treatment with cancer chemotherapy.癌症化疗后突变频率增加。
Cancer Res. 1985 Jun;45(6):2873-7.
6
Chromosome aberration and mitotic activity in human peripheral blood lymphocytes following in vitro action of platinum cytostatics cis-DDP and EM-Pt.顺铂和顺铂乙酯体外作用后人外周血淋巴细胞中的染色体畸变及有丝分裂活性
Neoplasma. 1986;33(4):465-9.
7
Second malignancies following testicular cancer, ovarian cancer and Hodgkin's disease: an international collaborative study among cancer registries.睾丸癌、卵巢癌和霍奇金病后的第二原发性恶性肿瘤：癌症登记处之间的一项国际合作研究。
Int J Cancer. 1987 May 15;39(5):571-85. doi: 10.1002/ijc.2910390506.
8
Cytogenetic study of a testicular tumor in a translocation (13;14) carrier.对一名13号与14号染色体易位携带者的睾丸肿瘤进行细胞遗传学研究。
Cancer Genet Cytogenet. 1987 Jun;26(2):299-307. doi: 10.1016/0165-4608(87)90064-1.
9
Chromosome characteristics of therapy-related acute non-lymphocytic leukemia and preleukemia: possible implications for pathogenesis of the disease.治疗相关性急性非淋巴细胞白血病和白血病前期的染色体特征：对疾病发病机制的可能影响。
Leuk Res. 1987;11(4):315-8. doi: 10.1016/0145-2126(87)90174-3.
10
Variation in spontaneous chromosomal damage as a function of biologic rhythms in women.女性自发染色体损伤随生物节律的变化
Hum Genet. 1988 May;79(1):83-5. doi: 10.1007/BF00291717.