小鼠对卵清蛋白口服耐受的遗传控制
Genetic control of oral tolerance to ovalbumin in mice.
作者信息
Lamont A G, Mowat A M, Browning M J, Parrott D M
机构信息
Department of Bacteriology and Immunology, Western Infirmary, Glasgow.
出版信息
Immunology. 1988 Apr;63(4):737-9.
Abstract
We have investigated the genetic basis of oral tolerance to OVA in a number of inbred mouse strains. Our results emphasise the efficiency of the oral route for inducing tolerance and provide evidence for both MHC and non-MHC linked control of oral tolerance.
摘要
我们已经在多个近交系小鼠品系中研究了对卵清蛋白（OVA）口服耐受的遗传基础。我们的结果强调了口服途径诱导耐受的效率，并为主要组织相容性复合体（MHC）和非MHC相关的口服耐受控制提供了证据。
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Genetic control of oral tolerance to ovalbumin in mice.小鼠对卵清蛋白口服耐受的遗传控制
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The absence of gut flora has no effect on the induction of oral tolerance to ovalbumin.肠道菌群的缺失对诱导针对卵清蛋白的口服耐受性没有影响。
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Induction of ovalbumin-specific tolerance by oral administration of Lactococcus lactis secreting ovalbumin.通过口服分泌卵清蛋白的乳酸乳球菌诱导卵清蛋白特异性耐受。
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本文引用的文献
1
Genetic differences in immune exclusion and partial tolerance to ingested antigens.免疫排斥及对摄入抗原的部分耐受性中的基因差异。
Clin Exp Immunol. 1983 Jun;52(3):678-84.
2
Oral tolerance and accessory-cell function of Peyer's patches.派尔集合淋巴结的口服耐受与辅助细胞功能。
Ann N Y Acad Sci. 1983 Jun 30;409:145-63. doi: 10.1111/j.1749-6632.1983.tb26865.x.
3
A genetically determined lack of oral tolerance to ovalbumin is due to failure of the immune system to respond to intestinally derived tolerogen.对卵清蛋白的口腔耐受性在基因上的缺失，是由于免疫系统未能对肠道来源的耐受原作出反应所致。
Eur J Immunol. 1987 Nov;17(11):1673-6. doi: 10.1002/eji.1830171126.
4
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An HLA-D region restriction fragment length polymorphism associated with celiac disease.一种与乳糜泻相关的HLA - D区域限制性片段长度多态性。
J Exp Med. 1986 Jul 1;164(1):333-8. doi: 10.1084/jem.164.1.333.
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Increased prostaglandin production by human monocytes after membrane receptor activation.膜受体激活后人单核细胞前列腺素生成增加。
J Immunol. 1979 Jul;123(1):115-20.
7
Genetic control of tolerance induction to human gamma-globulin in mice.小鼠对人γ-球蛋白耐受性诱导的遗传控制。
J Immunol. 1978 Oct;121(4):1251-6.
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