Mithra Prasanna, Khatib Mahalaqua Nazli, Sinha Anju Pradhan, Kumar Nithin, Holla Ramesh, Unnikrishnan Bhaskaran, Vijayamma Ratheebhai, Nair N Sreekumaran, Gaidhane Abhay, Quazi Zahiruddin Syed
Department of Community Medicine, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India.
Division of Evidence Synthesis, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences, Wardha, India.
Front Pediatr. 2021 Feb 16;8:549549. doi: 10.3389/fped.2020.549549. eCollection 2020.
Anemia is a public health problem that can lead to growth, cognitive, and motor impairments. To collate evidence on interventions for addressing childhood and adolescent anemia. In this overview of systematic reviews, we included Cochrane as well as non-Cochrane systematic reviews (SRs) irrespective of language and publication status. Two sets of review authors independently screened articles for eligibility and extracted data from relevant SRs. We present data in a tabular format and summarize results based on outcome reported, age of participants, and type of interventions. We also adopt a "measurement for change" approach to assess the utility of measurement for development of interventions in childhood and adolescent anemia. Our search yielded 2,601 records of which 31 SRs were found eligible for inclusion. Results were favorable for fortification and supplementation with clear reduction in the risk of anemia and increase in hemoglobin levels across all age groups. Other interventions reported by the SRs were inconclusive and suggest further research. Current evidence suggests that fortification or supplementation with iron and micronutrients leads to better reduction in the risk of anemia and improvements in hemoglobin levels among children and adolescents. Results of this overview can help decision makers in informing selection of interventions to address childhood and adolescent anemia. PROSPERO CRD42016053687.
贫血是一个公共卫生问题，可导致生长、认知和运动障碍。为了整理有关解决儿童和青少年贫血干预措施的证据。在这项系统评价综述中，我们纳入了Cochrane系统评价以及非Cochrane系统评价，无论其语言和发表状态如何。两组综述作者独立筛选文章以确定其是否符合纳入标准，并从相关系统评价中提取数据。我们以表格形式呈现数据，并根据报告的结果、参与者年龄和干预类型总结结果。我们还采用“变化测量”方法来评估测量在儿童和青少年贫血干预措施制定中的效用。我们的检索产生了2601条记录，其中31项系统评价被认为符合纳入标准。结果表明强化和补充措施效果良好，所有年龄组的贫血风险明显降低，血红蛋白水平升高。系统评价报告的其他干预措施尚无定论，需要进一步研究。目前的证据表明，补充铁和微量营养素可更好地降低儿童和青少年的贫血风险，并提高血红蛋白水平。本综述的结果可帮助决策者选择解决儿童和青少年贫血的干预措施。国际前瞻性系统评价注册库编号：CRD42016053687。
