Noori Ayush, Mezlini Aziz M, Hyman Bradley T, Serrano-Pozo Alberto, Das Sudeshna
Harvard College, Cambridge, MA 02138, United States of America.
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, United States of America.
Data Brief. 2021 Feb 11;35:106863. doi: 10.1016/j.dib.2021.106863. eCollection 2021 Apr.
In Noori et al. [1], we hypothesized that there is a shared gene expression signature underlying neurodegenerative proteinopathies including Alzheimer's disease (AD), Lewy body diseases (LBD), and the amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) spectrum. To test this hypothesis, we performed a systematic review and meta-analysis of 60 human central nervous system transcriptomic datasets in the public Gene Expression Omnibus and ArrayExpress repositories, comprising a total of 2,600 AD, LBD, and ALS-FTD patients and age-matched controls which passed our stringent quality control pipeline. Here, we provide the results of differential expression analyses with data quality reports for each of these 60 datasets. This atlas of differential expression across AD, LBD, and ALS-FTD may guide future work to elucidate the pathophysiological drivers of these individual diseases as well as the common substrate of neurodegeneration.
在努里等人的研究[1]中，我们假设在包括阿尔茨海默病（AD）、路易体病（LBD）以及肌萎缩侧索硬化症和额颞叶痴呆（ALS-FTD）谱系在内的神经退行性蛋白质病背后存在共同的基因表达特征。为了验证这一假设，我们对公共基因表达综合数据库（Gene Expression Omnibus）和ArrayExpress数据库中的60个人类中枢神经系统转录组数据集进行了系统综述和荟萃分析，这些数据集总共包含2600名AD、LBD和ALS-FTD患者以及通过我们严格质量控制流程的年龄匹配对照。在此，我们提供这60个数据集中每个数据集的差异表达分析结果及数据质量报告。这个跨越AD、LBD和ALS-FTD的差异表达图谱可能会为未来的研究提供指导，以阐明这些个体疾病的病理生理驱动因素以及神经退行性变的共同基础。
