N-异丙基-对碘安非他明在小鼠体内的生物分布。

Biodistribution of N-isopropyl-p-iodoamphetamine in mice.

作者信息

Hoshi H, Jinnouchi S, Watanabe K, Ueda T, Kinoshita K, Yamaguchi T, Tahara Y

机构信息

Department of Radiology, Miyazaki Medical College, Japan.

出版信息

Int J Rad Appl Instrum B. 1988;15(2):127-31. doi: 10.1016/0883-2897(88)90078-5.

DOI:10.1016/0883-2897(88)90078-5

PMID:3366615

Abstract

Biodistribution of N-isopropyl-p-iodoamphetamine (IMP) was evaluated in mice. After synthesis of IMP and exchange labeling with radioactive iodine, IMP was injected intravenously in male ddY mice. Activity in the brain reached 8.0 (%dose/g), at 10 min after injection and it was almost constant till 120 min. Activities in the lung and heart were high just after injection, decreased rapidly and was almost constant from 30 to 120 min. Activity in the liver increased slowly compared with other organs, and reached peak level at 60 min. In autoradiography, almost the same activity in the spinal cord as the brain was observed. Uptake and excretion of IMP were shown in kidneys and stomach, which may be the main route of the excretion of IMP and their metabolites. We concluded IMP showed good uptake in the central nervous system.

摘要

在小鼠体内评估了N-异丙基-p-碘安非他明（IMP）的生物分布。IMP合成并经放射性碘进行交换标记后，静脉注射到雄性ddY小鼠体内。注射后10分钟时，脑内活性达到8.0（%剂量/克），直至120分钟几乎保持恒定。肺和心脏中的活性在注射后即刻较高，随后迅速下降，从30分钟到120分钟几乎保持恒定。肝脏中的活性与其他器官相比增加缓慢，在60分钟时达到峰值水平。在放射自显影中，观察到脊髓中的活性与脑内几乎相同。IMP在肾脏和胃中有摄取和排泄，这可能是IMP及其代谢产物排泄的主要途径。我们得出结论，IMP在中枢神经系统中摄取良好。