Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Toulouse, France.
Center of Assistive Robotics and Rehabilitation for Longevity and Good Health, National Center for Geriatrics and Gerontology, 7-430 Morioka-cho, Obu, Aichi, 474-8511, Japan.
Eur Geriatr Med. 2021 Oct;12(5):973-980. doi: 10.1007/s41999-021-00473-9. Epub 2021 Mar 5.
This study examined the bidirectional relationship between depressive symptoms and physical performance in community-dwelling older people with subjective memory complaints.
Secondary analyses using data from the Multidomain Alzheimer Preventive Trial (MAPT) study were performed. The participants were 1679 subjects (female, 64.8%; mean age, 75.3 ± 4.4 years). The outcome measures were depressive symptoms assessed by the 15-item Geriatric Depression Scale (GDS) and physical performance assessed by the Short Physical Performance Battery (SPPB) and handgrip strength (HGS). All measurements were performed at baseline and at 6, 12, 24, and 36 months. The bidirectional relationships of GDS with SPPB and HGS were examined using mixed-effect regression analysis.
Baseline physical performance was significantly associated with a decreased GDS score (SPPB score: β = - 0.210, 95% confidence interval [CI], - 0.283 to - 0.137; HGS: β = - 0.038, 95% CI - 0.056 to - 0.019). The baseline GDS score was significantly associated with decreased physical performance (SPPB score: β = - 0.082, 95% CI - 0.107 to - 0.056; HGS: β = - 0.261, 95% CI - 0.370 to - 0.152).
Since depressive symptoms and physical performance had a bidirectional relationship, prevention or improvement of decreased physical performance could play a role in reducing depressive symptoms, and addressing depressive symptoms may play a role in improving physical performance.
NCT01513252.
本研究旨在探讨有主观记忆主诉的社区居住老年人中抑郁症状与身体表现之间的双向关系。
使用来自多领域阿尔茨海默病预防试验（MAPT）研究的数据进行二次分析。参与者为 1679 名受试者（女性，64.8%；平均年龄，75.3±4.4 岁）。结局指标为 15 项老年抑郁量表（GDS）评估的抑郁症状和短体表现电池（SPPB）和握力（HGS）评估的身体表现。所有测量均在基线和 6、12、24 和 36 个月时进行。使用混合效应回归分析检查 GDS 与 SPPB 和 HGS 的双向关系。
基线身体表现与 GDS 评分降低显著相关（SPPB 评分：β=−0.210，95%置信区间[CI]：−0.283 至−0.137；HGS：β=−0.038，95%CI：−0.056 至−0.019）。基线 GDS 评分与身体表现降低显著相关（SPPB 评分：β=−0.082，95%CI：−0.107 至−0.056；HGS：β=−0.261，95%CI：−0.370 至−0.152）。
由于抑郁症状和身体表现之间存在双向关系，预防或改善身体表现下降可能在降低抑郁症状方面发挥作用，而解决抑郁症状可能在改善身体表现方面发挥作用。
NCT01513252。
