State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District 100101, Beijing, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Chaoyang District 100101, Beijing, China; Beijing Institute of Stem Cell and Regenerative Medicine, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 101408, China.
Cell Stem Cell. 2021 Mar 4;28(3):361-363. doi: 10.1016/j.stem.2021.02.021.
Previous work demonstrating the existence of intermediate pluripotency states in post-implantation embryos had ignited a debate on whether "formative" pluripotency can be stabilized in pluripotent stem cell (PSC) lines. In this issue of Cell Stem Cell, two papers show that polarized epithelial and germ cell-competent formative PSCs can be maintained in modified activin-dependent conditions.
先前的工作表明，在着床后胚胎中存在中间多能性状态，这引发了关于“形成性”多能性是否可以在多能干细胞 (PSC) 系中稳定存在的争论。在本期《Cell Stem Cell》杂志上，两篇论文表明，在经过改良的依赖激活素的条件下，可以维持具有极性上皮和生殖细胞能力的形成性多能干细胞。
