靶向肿瘤干细胞的能量代谢：白血病和实体瘤的进展与挑战。
Targeting Energy Metabolism in Cancer Stem Cells: Progress and Challenges in Leukemia and Solid Tumors.
机构信息
Princess Margaret Cancer Centre, 101 College St. Toronto, ON M5G 1L7, Canada.
Division of Hematology, University of Colorado, 12700 East 19th Ave., Aurora, CO 80045, USA.
出版信息
Cell Stem Cell. 2021 Mar 4;28(3):378-393. doi: 10.1016/j.stem.2021.02.013.
Abstract
Malignant stem cells have long been considered a key therapeutic target in leukemia. Therapeutic strategies designed to target the fundamental biology of leukemia stem cells while sparing normal hematopoietic cells may provide better outcomes for leukemia patients. One process in leukemia stem cell biology that has intriguing therapeutic potential is energy metabolism. In this article we discuss the metabolic properties of leukemia stem cells and how targeting energy metabolism may provide more effective therapeutic regimens for leukemia patients. In addition, we highlight the similarities and differences in energy metabolism between leukemia stem cells and malignant stem cells from solid tumors.
摘要
恶性干细胞一直被认为是白血病治疗的关键靶点。旨在靶向白血病干细胞的基本生物学特性而不损伤正常造血细胞的治疗策略可能为白血病患者提供更好的治疗效果。白血病干细胞生物学中的一个具有诱人治疗潜力的过程是能量代谢。本文讨论了白血病干细胞的代谢特性以及靶向能量代谢如何为白血病患者提供更有效的治疗方案。此外，我们还强调了白血病干细胞与实体瘤恶性干细胞在能量代谢方面的相似性和差异性。
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