Li Yuhan, Zhang Xinyu, Wang Jianhua, Wang Kexin, Li Boya, Qiao Xianghe, He Wei, Cai Jinghua, Liu Danfeng, Yang Lei-Lei
Department of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Theranostics. 2025 Mar 24;15(10):4708-4733. doi: 10.7150/thno.106291. eCollection 2025.
Manipulation of the biochemical composition of the tumor microenvironment (TME) is a thriving research area in cancer treatment. Adenosine triphosphate (ATP), a key biochemical component, serves as an energy source for cancer cell proliferation. Notably, ATP can also act as a potent signal transducer to prime anti-tumor immune responses. There is increasing attention given to both the tumor-promoting and tumor-inhibiting roles of ATP in the context of possible new treatments for cancer. ATP levels in the TME are known to be significantly greater than in non-tumor tissues. This disparity presents an opportunity to exploit the ATP response for the delivery of anti-tumor drugs and tumor diagnosis. In this article, we provide a comprehensive overview of the existing strategies and mechanisms for ATP-based therapy and cancer diagnosis. We also discuss the current challenges in the field and propose potential areas for future research, to provide researchers with insights to further investigate the potential of ATP in cancer theranostics.
对肿瘤微环境（TME）生化组成的调控是癌症治疗中一个蓬勃发展的研究领域。三磷酸腺苷（ATP）作为一种关键的生化成分，是癌细胞增殖的能量来源。值得注意的是，ATP还可作为一种强大的信号转导分子，启动抗肿瘤免疫反应。在癌症可能的新治疗背景下，ATP的促肿瘤和抑肿瘤作用都受到了越来越多的关注。已知TME中的ATP水平显著高于非肿瘤组织。这种差异为利用ATP反应进行抗肿瘤药物递送和肿瘤诊断提供了机会。在本文中，我们全面概述了基于ATP的治疗和癌症诊断的现有策略和机制。我们还讨论了该领域当前面临的挑战，并提出了未来潜在的研究领域，以为研究人员提供深入见解，进一步探究ATP在癌症诊疗中的潜力。
