Departments of Medicine, Microbiology and Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Cell. 2021 Mar 4;184(5):1139-1141. doi: 10.1016/j.cell.2021.02.005.
Clonal hematopoiesis, defined as the presence of expanded somatic blood cell clones, is associated with about a doubling in the risk of coronary heart disease in humans. Heyde and colleagues now provide evidence that clonal hematopoiesis results largely from increased stem cell proliferation, which is, in turn, stimulated by atherosclerosis.
克隆性造血，定义为存在扩增的体细胞造血细胞克隆，与人类冠心病风险增加约一倍有关。Heyde 及其同事现在提供的证据表明，克隆性造血主要源于干细胞增殖增加，而这反过来又受到动脉粥样硬化的刺激。
