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克隆性造血——一种改变老年人病理过程的新实体。

Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly.

作者信息

Belotserkovskaya Ekaterina, Golotin Vasily, Uyanik Burhan, Demidov Oleg N

机构信息

Institute of Cytology RAS, 4 Tikhoretskii prospect, St. Petersburg, 194064, Russia.

Saint Petersburg bra-nch of "VNIRO" ("Gos-NOIRH" named after L.S. Berg), Saint Petersburg, Russia.

出版信息

Cell Death Discov. 2023 Sep 19;9(1):345. doi: 10.1038/s41420-023-01590-z.

Abstract

Progress in the development of new sequencing techniques with wider accessibility and higher sensitivity of the protocol of deciphering genome particularities led to the discovery of a new phenomenon - clonal haematopoiesis. It is characterized by the presence in the bloodstream of elderly people a minor clonal population of cells with mutations in certain genes, but without any sign of disease related to the hematopoietic system. Here we will review this recent advancement in the field of clonal haematopoiesis and how it may affect the disease's development in old age.

摘要

新测序技术的发展取得了进展,这些技术具有更广泛的可及性和更高的灵敏度来解读基因组特性,从而发现了一种新现象——克隆性造血。其特征是在老年人的血液中存在一小部分具有某些基因突变的克隆细胞群,但没有任何与造血系统相关疾病的迹象。在此,我们将回顾克隆性造血领域的这一最新进展,以及它如何影响老年疾病的发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64e0/10509183/700c41e7fb78/41420_2023_1590_Fig1_HTML.jpg

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