VST Glaucoma Centre, Dr. Kallam Anji Reddy Campus (N.S.C., R.C.K.), L. V. Prasad Eye Institute, Banjara Hills, Hyderabad, India; Allen Foster Community Eye Health Research Centre, Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye Care (N.S.C., R.C.K., S.M., A.L.M., P.G., S.B., K.S., G.N.R.), L. V. Prasad Eye Institute, Banjara Hills, Hyderabad, India.
VST Glaucoma Centre, Dr. Kallam Anji Reddy Campus (N.S.C., R.C.K.), L. V. Prasad Eye Institute, Banjara Hills, Hyderabad, India; Allen Foster Community Eye Health Research Centre, Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye Care (N.S.C., R.C.K., S.M., A.L.M., P.G., S.B., K.S., G.N.R.), L. V. Prasad Eye Institute, Banjara Hills, Hyderabad, India; Brien Holden Eye Research Centre (R.C.K., S.M., A.L.M., P.G., S.B., K.S., S.C., G.N.R.), L. V. Prasad Eye Institute, Banjara Hills, Hyderabad, India; School of Optometry and Vision Science, University of New South Wales (R.C.K.), Sydney, Australia; School of Medicine and Dentistry, University of Rochester (R.C.K.), Rochester, NY, USA.
Am J Ophthalmol. 2021 Sep;229:34-44. doi: 10.1016/j.ajo.2021.02.030. Epub 2021 Mar 2.
To report on the 15-year incidence of primary angle closure disease (PACD) among participants aged ≥40 years in rural southern India DESIGN: Population-based longitudinal incidence rate study METHODS: Setting: 3 rural study centres.
Phakic participants aged ≥40 years who participated in both examination time points.
All participants at the baseline and at the mean 15-year follow-up visit underwent a detailed interview, anthropometry, blood pressure measurement, and comprehensive eye examination. Automated perimetry was attempted based on predefined criteria. Main outcome measures included development of any form of PACD, as defined by the International Society for Geographical and Epidemiological Ophthalmology (ISGEO), during the follow-up period in phakic participants, who did not have the disease at baseline.
We analyzed data obtained from 1,197 (81.4% out of available 1,470) participants to calculate the incidence of the disease. The mean age (standard deviation) of the study participants at the baseline was 50.2 (8.1) years, with 670 male (45.5%) and 800 female (54.4%) participants. The incidence rate per 100 person-years (95% confidence interval) for primary angle closure suspect, primary angle closure, and primary angle closure glaucoma was 8.8 (8.4, 9.2), 6.2 (5.9, 6.6), and 1.6 (1.4, 1.8), respectively. Thus, the incidence of all forms of PACD was 16.4 (15.9, 17) per 100 person-years. On logistic regression analysis, female gender was a significant risk factor whereas presence of myopia was protective.
This study reports long-term incidence of PACD from rural India. It has implications for eye health care policies, strategies, and planning.
报告印度南部农村≥40 岁人群原发性闭角型青光眼（PACG）的 15 年发病情况。
基于人群的纵向发病率研究。
地点：3 个农村研究中心。
参加过两次检查的≥40 岁有晶状体的参与者。
所有参与者在基线和平均 15 年随访时接受详细的访谈、人体测量、血压测量和全面的眼科检查。根据预设标准尝试进行自动视野检查。主要观察指标包括在无晶状体参与者的随访期间，根据国际地理和流行病学眼科协会（ISGEO）定义，任何形式的 PACG 的发展。
我们分析了从 1197 名（可获得的 1470 名参与者中的 81.4%）参与者中获得的数据，以计算疾病的发病率。研究参与者的平均年龄（标准差）在基线时为 50.2（8.1）岁，其中 670 名男性（45.5%）和 800 名女性（54.4%）。原发性闭角型青光眼可疑、原发性闭角型青光眼和原发性闭角型青光眼的年发病率（95%置信区间）分别为 8.8（8.4，9.2）、6.2（5.9，6.6）和 1.6（1.4，1.8）。因此，所有形式的 PACG 的发病率为 16.4（15.9，17）/100 人年。在逻辑回归分析中，女性性别是一个显著的危险因素，而近视是保护性的。
本研究报告了印度农村地区 PACG 的长期发病率。这对眼部保健政策、策略和规划具有重要意义。
