Papazoglou Anthia, Conen Anna, Haubitz Sebastian, Tschopp Markus, Guignard Viviane J, Menke Marcel N, Enz Tim J
Department of Ophthalmology, Cantonal Hospital Aarau, 5000 Aarau, Switzerland.
Department of Infectious Diseases and Hospital Hygiene, Cantonal Hospital Aarau, 5000 Aarau, Switzerland.
J Clin Med. 2021 Feb 24;10(5):896. doi: 10.3390/jcm10050896.
Postmortem pathological examinations, animal studies, and anecdotal reports suggest that coronavirus disease 2019 (COVID-19) could potentially affect intraocular tissue. However, published evidence is scarce and conflicting. In our study, we screened 100 eyes of 50 patients hospitalized for COVID-19. Relevant medical and ophthalmological history was assessed as well as symptoms, laboratory results, specific treatments, clinical course, and outcome. Ophthalmic exams including assessment of best corrected visual acuity (BCVA), intraocular pressure (IOP), color perception, ocular motility, ophthalmoscopy as well as optical coherence tomography (OCT) of the macula and the optic disc was performed at hospital admission and 29 to 192 days later. Of the 50 patients included, 14 (28%) were female. Median age was 64.5 (range 29-90) years. COVID-19 severity was mild in 15 (30%), severe in 30 (60%), and critical in five cases (10%). At baseline, median BCVA was 0.1 (0-1.8) Logarithm of the Minimum Angle of Resolution (LogMAR) and median IOP was 16 (8-22) mmHg. At follow-up, no relevant changes in BCVA and IOP were documented. No signs of active intraocular inflammation or optic nerve affection were found and OCT findings were widely stable during the observation period. Our findings suggest that COVID-19 does not regularly affect intraocular tissue.
尸检病理检查、动物研究及轶事报告表明，2019冠状病毒病（COVID-19）可能会影响眼内组织。然而，已发表的证据稀少且相互矛盾。在我们的研究中，我们对50例因COVID-19住院患者的100只眼睛进行了筛查。评估了相关的医学和眼科病史以及症状、实验室检查结果、具体治疗情况、临床病程和预后。在入院时以及29至192天后进行了眼科检查，包括最佳矫正视力（BCVA）、眼压（IOP）、色觉、眼球运动、检眼镜检查以及黄斑和视盘的光学相干断层扫描（OCT）。纳入的50例患者中，14例（28%）为女性。中位年龄为64.5岁（范围29 - 90岁）。15例（30%）COVID-19病情为轻度，30例（60%）为重度，5例（10%）为危重症。基线时，BCVA中位数为0.1（0 - 1.8）最小分辨角对数（LogMAR），IOP中位数为16（8 - 22）mmHg。随访时，未记录到BCVA和IOP的相关变化。未发现眼内有活动性炎症或视神经受累的迹象，且在观察期内OCT检查结果基本稳定。我们的研究结果表明，COVID-19通常不会影响眼内组织。
