De Luca Maria, Bryan David R, Hunter Gary R
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Biomolecules. 2021 Feb 24;11(3):342. doi: 10.3390/biom11030342.
Syndecans (SDCs) are transmembrane proteins that are present on most cell types where they play a role in multiple physiological processes, including cell-matrix adhesion and inflammation. Growing evidence suggests that elevated levels of both shed SDC1 and SDC4 are associated with hypertension and cardiovascular diseases, but their relationships with cardiovascular risk factors in healthy individuals are unknown. The primary objective of this study was to investigate whether serum levels of SDC4 and SDC1 were associated with body composition, hemodynamic parameters, pro-inflammatory cytokine concentrations, and urinary noradrenaline and dopamine levels in healthy women (17 African American and 20 European American) between the ages of 20 and 40 years old. Univariate analyses revealed only a significant ( < 0.05) inverse correlation between serum SDC1 and body fat percentage. On the other hand, serum SDC4 was positively correlated with systolic blood pressure, diastolic blood pressure, and urinary levels of noradrenaline and dopamine. Serum SDC4 was also a significant predictor of systolic blood pressure in a multivariate regression model that included fat-free mass and urinary dopamine levels as significant independent variables. The result did not change even adjusting for race. Our findings indicate that SDC4 has an important role in the physiological regulation of blood pressure.
Syndecans（SDCs）是跨膜蛋白，存在于大多数细胞类型中，在多种生理过程中发挥作用，包括细胞与基质的粘附和炎症。越来越多的证据表明，脱落的SDC1和SDC4水平升高与高血压和心血管疾病有关，但它们与健康个体心血管危险因素之间的关系尚不清楚。本研究的主要目的是调查20至40岁健康女性（17名非裔美国人和20名欧裔美国人）血清中SDC4和SDC1水平是否与身体成分、血流动力学参数、促炎细胞因子浓度以及尿去甲肾上腺素和多巴胺水平相关。单因素分析仅显示血清SDC1与体脂百分比之间存在显著（<0.05）负相关。另一方面，血清SDC4与收缩压、舒张压以及尿去甲肾上腺素和多巴胺水平呈正相关。在一个多变量回归模型中，血清SDC4也是收缩压的显著预测因子，该模型将去脂体重和尿多巴胺水平作为显著的独立变量。即使对种族进行调整，结果也没有改变。我们的研究结果表明，SDC4在血压的生理调节中起重要作用。
