Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Blvd, Birmingham, AL, 35294-3360, USA.
Aging Clin Exp Res. 2022 Oct;34(10):2541-2545. doi: 10.1007/s40520-022-02210-z. Epub 2022 Aug 6.
Aging is accompanied by a low-grade proinflammatory status that plays a role in age-related vascular alterations. Syndecan-4 (SDC4) is a key component of the endothelial glycocalyx, and its extracellular domain can be shed by matrix metalloproteinase-9 (MMP-9). In vitro studies demonstrated that MMP-9-mediated shedding of SDC4 is induced by tumor necrosis factor-α (TNF- α) in human endothelial cells. However, the relationship between circulating shed SDC4, systemic inflammation, and age-related vascular alterations remains unknown. Here, we used linear regression models to examine the associations of serum SDC4 levels with cardiovascular hemodynamic phenotypes, serum MMP-9, and serum TNF-α and inteleukin-6 in healthy older women (n = 74). Serum SDC4 was not associated with proinflammatory cytokines or arterial elasticity. Nevertheless, we found significant correlations of SDC4 with MMP-9, heart rate, left ventricular ejection time, systemic vascular resistance, and blood pressure. Our preliminary evidence suggests that systemic inflammation might not induce SDC4 shedding in healthy aging.
衰老是伴随着低度炎症状态的，这种状态在与年龄相关的血管改变中起作用。硫酸乙酰肝素蛋白聚糖-4（SDC4）是血管内皮糖萼的关键组成部分，其细胞外结构域可被基质金属蛋白酶-9（MMP-9）分解。体外研究表明，肿瘤坏死因子-α（TNF-α）可诱导人内皮细胞中 MMP-9 介导的 SDC4 脱落。然而，循环中脱落的 SDC4、全身炎症与与年龄相关的血管改变之间的关系尚不清楚。在这里，我们使用线性回归模型来检查血清 SDC4 水平与心血管血流动力学表型、血清 MMP-9、血清 TNF-α和白细胞介素-6在健康老年女性（n=74）中的相关性。血清 SDC4 与促炎细胞因子或动脉弹性无关。然而，我们发现 SDC4 与 MMP-9、心率、左心室射血时间、全身血管阻力和血压呈显著相关。我们的初步证据表明，在健康衰老过程中，全身炎症可能不会诱导 SDC4 脱落。
