Törholm C, Hedström S A, Herrlin K, Johnell O, Lidgren L
Department of Infectious Diseases, University Hospital, Lund, Sweden.
J Pediatr Orthop. 1988 May-Jun;8(3):326-32. doi: 10.1097/01241398-198805000-00014.
The clinical, histologic and radiographic picture in 16 cases in 15 patients with nonfistulating chronic progressive osteoblastic osteomyelitis of a long tubular bone which started in childhood is presented. All patients had severe pain at rest or weightbearing. Histology showed an increase of active osteoblasts. Low virulent bacteria were found in one-fourth of the patients. To reduce the osteoblastic activity, nonsteroidal antiinflammatory treatment was combined with surgical and antibiotic treatment. Eleven patients were pain-free at follow-up (average 47 months), 3 had reduced pain, and 1 patient did not respond to treatment.
本文呈现了15例患者中16例长管状骨非瘘管性慢性进行性成骨性骨髓炎的临床、组织学和影像学表现，这些病例均始于儿童期。所有患者在静息或负重时均有剧痛。组织学显示活跃成骨细胞增多。四分之一的患者发现低毒力细菌。为降低成骨活性，非甾体抗炎治疗与手术及抗生素治疗相结合。随访时11例患者无痛（平均47个月），3例疼痛减轻，1例患者对治疗无反应。
