Ogino Noriyoshi, Ikeda Fusao, Namba Shihoko, Ohkubo Shinnosuke, Nishimura Tomoaki, Okada Hiroyuki, Hirohata Satoshi, Suganuma Narufumi, Ogino Keiki
Department of Environmental Medicine, Kochi Medical School, Kohasu, Oko-cho, Nankoku City 783-8505, Japan.
Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Iseigaoka 1-1, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Diagnostics (Basel). 2021 Feb 16;11(2):317. doi: 10.3390/diagnostics11020317.
While plasma arginase-1 has been suggested as a biomarker of mental status in healthy individuals, it has not been evaluated in patients with chronic liver disease. This cross-sectional study investigated the utility of plasma arginase-1 for screening mental status in patients with chronic liver disease. This study included outpatients with chronic liver disease who underwent regular check-ups at Okayama University Hospital between September 2018 and January 2019. In addition to the standard blood tests, the plasma arginase-1 level was analyzed. The patients' mental status was assessed using the Japanese version of the General Health Questionnaire-28 (GHQ-28). The associations between mental status and various parameters, including plasma arginase-1, were investigated using logistic regression analysis. Among 114 participating patients, 8 were excluded, comprising 6 with insufficient blood samples for plasma arginase-1 measurement and 2 with incomplete questionnaires. Multivariate binomial logistic regression analysis revealed that plasma arginase-1 was significantly and negatively associated with the GHQ-total score, especially somatic symptoms. Therefore, plasma arginase-1 may be a useful biomarker for assessing the mental status of outpatients with chronic liver disease.
虽然血浆精氨酸酶-1已被认为是健康个体精神状态的生物标志物，但尚未在慢性肝病患者中进行评估。这项横断面研究调查了血浆精氨酸酶-1在筛查慢性肝病患者精神状态方面的效用。本研究纳入了2018年9月至2019年1月在冈山大学医院接受定期检查的慢性肝病门诊患者。除了标准血液检查外，还分析了血浆精氨酸酶-1水平。使用日本版的一般健康问卷-28（GHQ-28）评估患者的精神状态。使用逻辑回归分析研究精神状态与包括血浆精氨酸酶-1在内的各种参数之间的关联。在114名参与患者中，8名被排除，包括6名血浆精氨酸酶-1测量血样不足的患者和2名问卷不完整的患者。多变量二项逻辑回归分析显示，血浆精氨酸酶-1与GHQ总分，尤其是躯体症状显著负相关。因此，血浆精氨酸酶-1可能是评估慢性肝病门诊患者精神状态的有用生物标志物。
