Hajduch Eric, Lachkar Floriane, Ferré Pascal, Foufelle Fabienne
Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, 75006 Paris, France.
Institute of Cardiometabolism and Nutrition (ICAN), Hôpital Pitié-Salpêtrière, AP-HP, 75013 Paris, France.
J Clin Med. 2021 Feb 16;10(4):792. doi: 10.3390/jcm10040792.
Non-alcoholic fatty liver disease is one of the most common chronic liver diseases, ranging from simple steatosis to steatohepatitis, fibrosis, and cirrhosis. Its prevalence is rapidly increasing and presently affects around 25% of the general population of Western countries, due to the obesity epidemic. Liver fat accumulation induces the synthesis of specific lipid species and particularly ceramides, a sphingolipid. In turn, ceramides have deleterious effects on hepatic metabolism, a phenomenon called lipotoxicity. We review here the evidence showing the role of ceramides in non-alcoholic fatty liver disease and the mechanisms underlying their effects.
非酒精性脂肪性肝病是最常见的慢性肝病之一，范围从单纯性脂肪变性到脂肪性肝炎、纤维化和肝硬化。由于肥胖症的流行，其患病率正在迅速上升，目前影响着西方国家约25%的普通人群。肝脏脂肪堆积会诱导特定脂质种类的合成，尤其是神经酰胺，一种鞘脂。反过来，神经酰胺对肝脏代谢具有有害影响，这种现象称为脂毒性。我们在此综述显示神经酰胺在非酒精性脂肪性肝病中的作用及其作用机制的证据。
