School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Bioluminescent Superbugs Lab, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Molecules. 2021 Feb 19;26(4):1094. doi: 10.3390/molecules26041094.
Antimicrobial bioassay-guided fractionation of the endophytic fungi led to the isolation of a new unsymmetrical naphthoquinone dimer, neofusnaphthoquinone B (), along with four known natural products (-). Structure elucidation was conducted by nuclear magnetic resonance (NMR) spectroscopic methods, and the antimicrobial activity of all the natural products was investigated, revealing to be moderately active towards methicillin-resistant (MRSA) with a minimum inhibitory concentration (MIC) of 16 µg/mL.
基于抗菌活性的导向分离，从内生真菌中分离得到一个新的非对称萘醌二聚体——新呋咱萘醌 B（），同时还分离得到四个已知天然产物（-）。通过核磁共振（NMR）波谱方法进行结构鉴定，所有天然产物的抗菌活性均进行了研究，结果表明，对耐甲氧西林金黄色葡萄球菌（MRSA）具有中等活性，最低抑菌浓度（MIC）为 16 µg/mL。
Zotero 插件