GKK1032C，一种新的来自内生真菌 Penicillium sp. CPCC 400817 的生物碱化合物，对耐甲氧西林金黄色葡萄球菌具有活性。
GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin-resistant S. aureus.
机构信息
CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
出版信息
J Antibiot (Tokyo). 2019 Apr;72(4):237-240. doi: 10.1038/s41429-019-0144-5. Epub 2019 Feb 8.
Five alkaloid compounds (1-5), including one new compound, GKK1032C (1), and four known compounds, pyrrospirones E (2) and F (3), and GKK1032B (4) and A2 (5) were isolated from the culture of endophytic fungus Penicillium sp. CPCC 400817. The planar structures of all compounds were elucidated by NMR and MS spectra. The relative configuration of new compound GKK1032C (1) was deduced from the vicinal J-values and ROESY spectral data. Compound 1 exhibited potent antibacterial activity against methicillin-resistant Staphylococcus aureus with an MIC value of 1.6 μg ml.
从内生真菌青霉 CPCC 400817 的培养物中分离得到 5 种生物碱化合物（1-5），包括 1 个新化合物 GKK1032C（1）和 4 个已知化合物吡咯螺酮 E（2）和 F（3）以及 GKK1032B（4）和 A2（5）。通过 NMR 和 MS 谱确定了所有化合物的平面结构。根据相邻 J 值和 ROESY 谱数据推断出新化合物 GKK1032C（1）的相对构型。化合物 1 对耐甲氧西林金黄色葡萄球菌表现出强烈的抗菌活性，MIC 值为 1.6 μg/ml。
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