从内生真菌拟茎点霉发酵产物中分离得到的异戊二烯基二苯醚衍生物。
Isopentylated diphenyl ether derivatives from the fermentation products of an endophytic fungus Phomopsis fukushii.
机构信息
Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co.Ltd, Kunming, 650231, China.
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, 650031, China.
出版信息
J Antibiot (Tokyo). 2018 Mar;71(3):359-362. doi: 10.1038/s41429-017-0006-y. Epub 2018 Jan 18.
Three new isopentylated diphenyl ethers, (1-3), together with two known isopentylated diphenyl ethers derivatives (4 and 5) were isolated from the fermentation products of an endophytic fungus Phomopsis fukushii. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compounds 1-3 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results showed that compounds 1-3 showed strong activity with diameter of inhibition zone (IZD) of 21.8 ± 2.4 mm, 16.8 ± 2.2 mm, and 15.6 ± 2.0 mm, respectively.
从内生真菌 Phomopsis fukushii 的发酵产物中分离得到了三种新的异戊二烯基二苯醚（1-3），以及两种已知的异戊二烯基二苯醚衍生物（4 和 5）。通过包括广泛的 1D 和 2D NMR 技术在内的光谱方法阐明了它们的结构。对化合物 1-3 进行了抗耐甲氧西林金黄色葡萄球菌（anti-MRSA）活性评估。结果表明，化合物 1-3 表现出强烈的活性，抑菌圈直径（IZD）分别为 21.8±2.4mm、16.8±2.2mm 和 15.6±2.0mm。
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