海洋海绵亚属的天然产物

College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 311121, China.

School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.

Molecules. 2021 Feb 19;26(4):1097. doi: 10.3390/molecules26041097.

Marine sponges are one of the prolific producers of bioactive natural products with therapeutic potential. As an important subgenus of , sponges are mainly distributed in the Mediterranean Sea and Atlantic area, and had been chemically investigated for over four decades. By an extensive literature search, this review first makes a comprehensive summary of all natural products from sponges and their endozoic microbes, as well as biological properties. Perspectives on strengthening the chemical study of sponges for new drug-lead discovery are provided in this work.

海洋海绵是具有治疗潜力的生物活性天然产物的丰富生产者之一。作为的一个重要亚属，海绵主要分布在地中海和大西洋地区，并且已经进行了超过四十年的化学研究。通过广泛的文献检索，本综述首先对来自的海绵及其内生微生物的所有天然产物以及生物特性进行了全面总结。本文就加强海绵的化学研究以发现新的药物先导化合物提供了一些观点。