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海洋海绵亚属的天然产物

Natural Products from the Marine Sponge Subgenus .

机构信息

College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 311121, China.

School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.

出版信息

Molecules. 2021 Feb 19;26(4):1097. doi: 10.3390/molecules26041097.

DOI:10.3390/molecules26041097
PMID:33669688
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7922958/
Abstract

Marine sponges are one of the prolific producers of bioactive natural products with therapeutic potential. As an important subgenus of , sponges are mainly distributed in the Mediterranean Sea and Atlantic area, and had been chemically investigated for over four decades. By an extensive literature search, this review first makes a comprehensive summary of all natural products from sponges and their endozoic microbes, as well as biological properties. Perspectives on strengthening the chemical study of sponges for new drug-lead discovery are provided in this work.

摘要

海洋海绵是具有治疗潜力的生物活性天然产物的丰富生产者之一。作为 的一个重要亚属，海绵主要分布在地中海和大西洋地区，并且已经进行了超过四十年的化学研究。通过广泛的文献检索，本综述首先对来自 的海绵及其内生微生物的所有天然产物以及生物特性进行了全面总结。本文就加强 海绵的化学研究以发现新的药物先导化合物提供了一些观点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd01/7922958/44f8a29d6b13/molecules-26-01097-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd01/7922958/15c78a1b2343/molecules-26-01097-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd01/7922958/535915aacdc6/molecules-26-01097-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd01/7922958/3c4f66223176/molecules-26-01097-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd01/7922958/5311a1a6d461/molecules-26-01097-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd01/7922958/34171ff9695b/molecules-26-01097-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd01/7922958/04d5eab1df72/molecules-26-01097-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd01/7922958/21979e7b930b/molecules-26-01097-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd01/7922958/513d7b934ac2/molecules-26-01097-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd01/7922958/7fc93d410486/molecules-26-01097-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd01/7922958/44f8a29d6b13/molecules-26-01097-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd01/7922958/15c78a1b2343/molecules-26-01097-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd01/7922958/535915aacdc6/molecules-26-01097-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd01/7922958/3c4f66223176/molecules-26-01097-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd01/7922958/5311a1a6d461/molecules-26-01097-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd01/7922958/34171ff9695b/molecules-26-01097-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd01/7922958/04d5eab1df72/molecules-26-01097-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd01/7922958/21979e7b930b/molecules-26-01097-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd01/7922958/513d7b934ac2/molecules-26-01097-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd01/7922958/7fc93d410486/molecules-26-01097-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd01/7922958/44f8a29d6b13/molecules-26-01097-g010.jpg

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本文引用的文献

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2
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Mar Drugs. 2019 Dec 3;17(12):682. doi: 10.3390/md17120682.
3
Can Stereoclusters Separated by Two Methylene Groups Be Related by DFT Studies? The Case of the Cytotoxic Meroditerpenes Halioxepines.两个亚甲基分隔的立体簇能否通过 DFT 研究相关？细胞毒性麦角甾二萜类化合物海鞘素的情况。
基于代谢组多样性和生物活性对从印度洋海绵中分离出的微生物进行优先级排序以发现天然产物。
Microorganisms. 2023 Mar 8;11(3):697. doi: 10.3390/microorganisms11030697.
J Nat Prod. 2018 Feb 23;81(2):343-348. doi: 10.1021/acs.jnatprod.7b00807. Epub 2018 Feb 2.
4
Cytotoxic Natural Products from Marine Sponge-Derived Microorganisms.来自海洋海绵衍生微生物的细胞毒性天然产物。
Mar Drugs. 2017 Mar 10;15(3):68. doi: 10.3390/md15030068.
5
Secondary Metabolites from the Marine Sponge Genus Phyllospongia.来自叶海绵属海洋海绵的次生代谢产物。
Mar Drugs. 2017 Jan 6;15(1):12. doi: 10.3390/md15010012.
6
The Saraine Alkaloids.萨赖因生物碱
Alkaloids Chem Biol. 2014;73:223-329. doi: 10.1016/B978-0-12-411565-1.00004-4. Epub 2013 Dec 25.
7
APS8, a polymeric alkylpyridinium salt blocks α7 nAChR and induces apoptosis in non-small cell lung carcinoma.APS8，一种聚合的烷基吡啶鎓盐，可阻断α7 nAChR 并诱导非小细胞肺癌细胞凋亡。
Mar Drugs. 2013 Jul 16;11(7):2574-94. doi: 10.3390/md11072574.
8
Toxicity of the synthetic polymeric 3-alkylpyridinium salt (APS3) is due to specific block of nicotinic acetylcholine receptors.合成聚合物 3-烷基吡啶鎓盐（APS3）的毒性是由于其对烟碱型乙酰胆碱受体的特异性阻断。
Toxicology. 2013 Jan 7;303:25-33. doi: 10.1016/j.tox.2012.10.013. Epub 2012 Nov 9.
9
The non-competitive acetylcholinesterase inhibitor APS12-2 is a potent antagonist of skeletal muscle nicotinic acetylcholine receptors.非竞争性乙酰胆碱酯酶抑制剂 APS12-2 是一种强效的骨骼肌烟碱型乙酰胆碱受体拮抗剂。
Toxicol Appl Pharmacol. 2012 Dec 1;265(2):221-8. doi: 10.1016/j.taap.2012.09.024. Epub 2012 Oct 6.
10
Cardiovascular effects induced by polymeric 3-alkylpyridinium salts from the marine sponge Reniera sarai.海洋海绵 Reniera sarai 衍生的聚合 3-烷基吡啶盐引起的心血管效应。
Toxicon. 2012 Nov;60(6):1041-8. doi: 10.1016/j.toxicon.2012.07.007. Epub 2012 Jul 27.