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来自海洋海绵衍生微生物的细胞毒性天然产物。

Cytotoxic Natural Products from Marine Sponge-Derived Microorganisms.

作者信息

Zhang Huawei, Zhao Ziping, Wang Hong

机构信息

School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.

出版信息

Mar Drugs. 2017 Mar 10;15(3):68. doi: 10.3390/md15030068.

DOI:10.3390/md15030068
PMID:28287431
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5367025/
Abstract

A growing body of evidence indicates that marine sponge-derived microbes possess the potential ability to make prolific natural products with therapeutic effects. This review for the first time provides a comprehensive overview of new cytotoxic agents from these marine microbes over the last 62 years from 1955 to 2016, which are assorted into seven types: terpenes, alkaloids, peptides, aromatics, lactones, steroids, and miscellaneous compounds.

摘要

越来越多的证据表明，源自海洋海绵的微生物具有产生大量具有治疗作用的天然产物的潜在能力。本综述首次全面概述了1955年至2016年这62年间从这些海洋微生物中发现的新型细胞毒性剂，它们分为七类：萜类、生物碱、肽类、芳香族化合物、内酯、类固醇和其他化合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c1c/5367025/74509f75e08e/marinedrugs-15-00068-ch018.jpg
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