Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Genes (Basel). 2021 Feb 11;12(2):261. doi: 10.3390/genes12020261.
Renal cell carcinoma is a term that represents multiple different disease processes, each driven by different genetic alterations, with distinct histology, and biological potential which necessitates divergent management strategies. This review discusses the genetic alterations seen in several forms of hereditary kidney cancer and how that knowledge can dictate when and how to intervene with a focus on the surgical management of these tumors.
肾细胞癌是一个术语，代表多种不同的疾病过程，每种疾病都由不同的遗传改变驱动，具有不同的组织学和生物学潜能，这需要不同的管理策略。这篇综述讨论了几种遗传性肾癌中可见的遗传改变，以及这些知识如何决定何时以及如何进行干预，重点是这些肿瘤的手术管理。
