Liberti Maria V, Locasale Jason W
Department of Molecular Biology and Genetics, Graduate Field of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY, USA; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Duke Molecular Physiology Institute, Duke Cancer Institute, Durham, NC, USA.
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Duke Molecular Physiology Institute, Duke Cancer Institute, Durham, NC, USA.
Trends Biochem Sci. 2016 Mar;41(3):211-218. doi: 10.1016/j.tibs.2015.12.001. Epub 2016 Jan 5.
Cancer cells rewire their metabolism to promote growth, survival, proliferation, and long-term maintenance. The common feature of this altered metabolism is the increased glucose uptake and fermentation of glucose to lactate. This phenomenon is observed even in the presence of completely functioning mitochondria and, together, is known as the 'Warburg Effect'. The Warburg Effect has been documented for over 90 years and extensively studied over the past 10 years, with thousands of papers reporting to have established either its causes or its functions. Despite this intense interest, the function of the Warburg Effect remains unclear. Here, we analyze several proposed explanations for the function of Warburg Effect, emphasize their rationale, and discuss their controversies.
癌细胞会重新调整其新陈代谢以促进生长、存活、增殖和长期维持。这种代谢改变的共同特征是葡萄糖摄取增加以及葡萄糖发酵生成乳酸。即使在存在完全正常功能的线粒体的情况下,这种现象也会出现,并且这一现象统称为“瓦伯格效应”。瓦伯格效应已被记录了90多年,在过去10年中得到了广泛研究,有成千上万篇论文报道已确定了其成因或功能。尽管人们对此兴趣浓厚,但瓦伯格效应的功能仍不清楚。在此,我们分析了关于瓦伯格效应功能的几种提出的解释,强调了它们的基本原理,并讨论了它们的争议之处。