Department of Neurodegenerative Disorders, Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, Poland.
Laboratory of Molecular Genetics, Department of Animal Molecular Biology, National Research Institute of Animal Production, 32-083 Balice, Poland.
Genes (Basel). 2021 Feb 11;12(2):262. doi: 10.3390/genes12020262.
In all sport disciplines, excellent coordination of movements is crucial for achieving mastery. The ability to learn new motor skills quickly and effectively is dependent on efficient myelination which varies between individuals. It has been suggested that these differences may play a role in athletic performance. The process of myelination is under transcriptional control by Myelin Regulatory Factor (MYRF) as well as other transcription factors (SOX10 and OLIG2). We analyze a panel of 28 single nucleotide polymorphisms (SNPs) located within the frequencies of common variants of , and genes in professional athletes compared to non-athletes. No significant differences were detected after correction for multiple testing by false discovery rate (FDR) for any of the models tested. However, some deviations from the expected distribution was found for seven SNPs (rs174528, rs139884, rs149435516 and rs2238001, rs7943728, rs61747222, and rs198459). The MYRF alleles rs7943728 and rs61747222 showed a correlation with the level of sport achievement among the athletes. Even though the athletes did not differ from the non-athlete controls in the distribution of most SNPs analyzed, some interesting differences of several variants were noted. Presented results indicate that genetic variants of and could be genetic factors weakly predisposing for successful athletic performance.
在所有运动项目中，出色的动作协调性对于掌握运动技能至关重要。快速有效地学习新运动技能的能力取决于髓鞘形成的效率，而髓鞘形成的效率在个体之间存在差异。有人认为，这些差异可能在运动表现中发挥作用。髓鞘形成过程受髓鞘调节因子（MYRF）以及其他转录因子（SOX10 和 OLIG2）的转录控制。我们分析了一组 28 个单核苷酸多态性（SNP），这些 SNP 位于职业运动员与非运动员相比的 、 和 基因的常见变异频率内。在对任何测试模型进行多重测试校正后，通过假发现率（FDR），没有检测到任何 SNP 存在显著差异。然而，对于七个 SNP（rs174528、rs139884、rs149435516 和 rs2238001、rs7943728、rs61747222 和 rs198459），发现了一些偏离预期分布的情况。MYRF 等位基因 rs7943728 和 rs61747222 与运动员的运动成绩水平相关。尽管运动员与非运动员对照组在分析的大多数 SNP 分布上没有差异，但注意到了几个变体的一些有趣差异。目前的结果表明，和 基因的遗传变异可能是对成功运动表现具有微弱倾向的遗传因素。
