Institute of Health and Biomedical Innovation-Centre for Children's Health Research, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD 4029, Australia.
Central Analytical Research Facility-Queensland University of Technology, Gardens Point, Brisbane, QLD 4000, Australia.
Int J Mol Sci. 2021 Feb 18;22(4):2024. doi: 10.3390/ijms22042024.
The reproductive status of dairy cows remains a challenge for dairy farmers worldwide, with impaired fertility linked to a significant reduction in herd profitability, due in part to impaired immunity, increased metabolic pressure, and longer postpartum anestrous interval (PPAI). Exosomes are nanovesicles released from a variety of cell types and end up in circulation, and carry proteins, bioactive peptides, lipids, and nucleic acids specific to the place of origin. As such, their role in health and disease has been investigated in humans and animals. This review discusses research into exosomes in the context of reproduction in dairy herds and introduces recent advances in mass-spectrometry (MS) based proteomics that have a potential to advance quantitative profiling of exosomal protein cargo in a search for early biomarkers of cattle fertility.
奶牛的繁殖状况仍然是全球奶农面临的一个挑战，由于免疫功能受损、代谢压力增加和产后乏情期（PPAI）延长，奶牛繁殖力下降与奶牛养殖利润显著降低有关。外泌体是一种由多种细胞类型释放的纳米囊泡，最终进入循环，并携带与起源地相关的蛋白质、生物活性肽、脂质和核酸。因此，它们在人类和动物的健康和疾病中的作用已经在研究中。本综述讨论了外泌体在奶牛群繁殖中的研究，并介绍了基于质谱（MS）的蛋白质组学的最新进展，这有可能推进对外泌体蛋白货物的定量分析，以寻找牛繁殖力的早期生物标志物。
