Department of Clinical Nutrition, Peking University People's Hospital, Beijing 100044, China.
Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.
Int J Environ Res Public Health. 2021 Feb 28;18(5):2349. doi: 10.3390/ijerph18052349.
Male sexual debility affects patients' confidence and damages the relationship between the couples and thus affects the stability of the family. This study aimed to investigate the effects of oligopeptides isolated from ginseng and oyster (GOPs and OOPs), separately and in combination, on sexual function in male mice. In the first experiment, male mice were randomly divided into five groups: vehicle control group; whey protein (125.0 mg kg) group; and GOPs 62.5, 125.0, and 250.0 mg kg groups. In the second experiment, male mice were randomly divided into five groups: vehicle control group, whey protein (160.0 mg kg) group, and OOPs 80.0, 160.0, and 320.0 mg kg groups. In the third experiment, male mice were randomly divided into six groups: vehicle control group, whey protein (222.5 mg kg) group, and GOPs + OOPs 62.5 + 160.0, 62.5 + 320.0, and 125.0 + 160.0, 125.0 + 320.0 mg kg groups. Test substances were given by gavage once a day for 30 days. The sexual behavior parameters, serum nitric oxide (NO), testosterone, cyclic guanosine monophosphate (cGMP), and phosphodiesterase-5 (PDE5) concentrations were detected. We found that GOPs at 250.0 mg kg improved male sexual behavior, NO, and testosterone content, whereas GOPs at 62.5 and 125.0 mg kg and OOPs at 80.0, 160, and 320 mg kg did not have significant effects. The combination of 62.5 mg kg GOPs + 160.0 mg kg OOPs and the combination of 125.0 mg kg GOPs + 320.0 mg kg OOPs improved male sexual behavior, serum NO, testosterone, and cGMP contents and decreased PDE5 content. The combination of 62.5 mg kg GOPs and 160.0 mg kg OOPs had the best effects among four combined groups. These results suggested that GOPs in combination with OOPs had the synergistic effects of enhancing male sexual function, probably via elevating serum testosterone, NO, and corpus cavernosum cGMP level and decreasing the corpus cavernosum PDE5 level. GOPs and OOPs could be novel natural agents for improving male sexual function.
男性性功能障碍会影响患者的信心，破坏夫妻关系，从而影响家庭的稳定性。本研究旨在探讨从人参和牡蛎中分离得到的寡肽（GOPs 和 OOPs）分别和联合应用对雄性小鼠性功能的影响。在第一个实验中，雄性小鼠随机分为五组： vehicle control group（空白对照组）；whey protein（乳清蛋白，125.0 mg kg）组；和 GOPs 62.5、125.0、250.0 mg kg 组。在第二个实验中，雄性小鼠随机分为五组： vehicle control group（空白对照组）；whey protein（乳清蛋白，160.0 mg kg）组；和 OOPs 80.0、160.0、320.0 mg kg 组。在第三个实验中，雄性小鼠随机分为六组： vehicle control group（空白对照组）；whey protein（乳清蛋白，222.5 mg kg）组；和 GOPs + OOPs 62.5 + 160.0、62.5 + 320.0、125.0 + 160.0、125.0 + 320.0 mg kg 组。用灌胃法每天给药一次，共 30 天。检测了性行为参数、血清一氧化氮（NO）、睾酮、环鸟苷酸（cGMP）和磷酸二酯酶-5（PDE5）的浓度。我们发现，250.0 mg kg 的 GOPs 改善了雄性性行为、NO 和睾酮含量，而 62.5 和 125.0 mg kg 的 GOPs 和 80.0、160 和 320 mg kg 的 OOPs 则没有显著影响。62.5 mg kg GOPs + 160.0 mg kg OOPs 和 125.0 mg kg GOPs + 320.0 mg kg OOPs 的联合应用改善了雄性性行为、血清 NO、睾酮和 cGMP 含量，并降低了 PDE5 含量。在四种联合组中，62.5 mg kg GOPs + 160.0 mg kg OOPs 的联合应用效果最好。这些结果表明，GOPs 与 OOPs 的联合应用具有增强雄性性功能的协同作用，可能是通过提高血清睾酮、NO 和海绵体 cGMP 水平，降低海绵体 PDE5 水平。GOPs 和 OOPs 可以成为改善男性性功能的新型天然药物。
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