Jiang Xuepeng, Huang Yanhua, Cheng Yiliang, Zhang Zhan, Shi Xiaolei, Qin Hantang
Department of Industrial and Manufacturing Systems Engineering, Iowa State University, Ames, IA 50011, USA.
Department of Food Science and Human Nutrition, Iowa State University, Ames, IA 50011, USA.
Polymers (Basel). 2021 Feb 28;13(5):749. doi: 10.3390/polym13050749.
Recently, increasing numbers of researchers are becoming interested in 3D bioprinting because it provides customizability and structural complexity, which is difficult for traditional subtractive manufacturing to achieve. One of the most critical factors in bioprinting is the material. Depending on the bio-applications, materials should be bio-inert or bio-active, non-toxic, and along with those characteristics, mechanical properties should also meet the applicational or manufacturing requirement. As previously validated for bioprinting, carboxymethyl cellulose (CMC) hydrogel is focused on the printability and release control test in this study. With a differentiated weight percentage of CMC hydrogels were used to 3D print capsules filled with food degradable colorant at designated voids to mimic capsules manufactured for oral delivery. Standard USP (United States Pharmacopeia) dissolution apparatus II (Paddle) evaluations were performed both on lyophilized and non-lyophilized printed capsules. The first-order model was selected due to high linear fitting regression. Upon 24 h dissolution, non-lyophilized capsules showed a different release efficiency when the CMC percentage varied, while lyophilized capsules showed no significant difference. This study signifies the possibility of customizing oral drug delivery by printing capsules with CMC hydrogel. The improved delivery efficiency demonstrated by capsules with post-process lyophilizing proposed potential optimization options for pharmaceutical manufacturing industries.
最近，越来越多的研究人员对3D生物打印感兴趣，因为它具有定制性和结构复杂性，这是传统减材制造难以实现的。生物打印中最关键的因素之一是材料。根据生物应用的不同，材料应具有生物惰性或生物活性、无毒，并且除了这些特性外，机械性能也应满足应用或制造要求。如先前在生物打印中得到验证的那样，羧甲基纤维素（CMC）水凝胶在本研究中重点进行了可打印性和释放控制测试。使用不同重量百分比的CMC水凝胶在指定空隙处3D打印填充有食品可降解着色剂的胶囊，以模拟用于口服给药的胶囊。对冻干和未冻干的打印胶囊都进行了标准美国药典（USP）溶出装置II（桨法）评估。由于线性拟合回归度高，选择了一级模型。在24小时溶出时，当CMC百分比变化时，未冻干的胶囊显示出不同的释放效率，而冻干的胶囊则没有显著差异。本研究表明了通过用CMC水凝胶打印胶囊来定制口服药物递送的可能性。后处理冻干的胶囊所展示出的提高的递送效率为制药行业提出了潜在的优化方案。
