Fahma Farah, Firmanda Afrinal, Cabral Jaydee, Pletzer Daniel, Fisher John, Mahadik Bhushan, Arnata I Wayan, Sartika Dewi, Wulandari Anting
Department of Agroindustrial Technology, Faculty of Agricultural Engineering and Technology, IPB University (Bogor Agricultural University), Bogor, Indonesia.
Department of Microbiology & Immunology, University of Otago, Dunedin, New Zealand.
3D Print Addit Manuf. 2023 Oct 1;10(5):1015-1035. doi: 10.1089/3dp.2021.0327. Epub 2023 Oct 10.
Wounds are skin tissue damage due to trauma. Many factors inhibit the wound healing phase (hemostasis, inflammation, proliferation, and alteration), such as oxygenation, contamination/infection, age, effects of injury, sex hormones, stress, diabetes, obesity, drugs, alcoholism, smoking, nutrition, hemostasis, debridement, and closing time. Cellulose is the most abundant biopolymer in nature which is promising as the main matrix of wound dressings because of its good structure and mechanical stability, moisturizes the area around the wound, absorbs excess exudate, can form elastic gels with the characteristics of bio-responsiveness, biocompatibility, low toxicity, biodegradability, and structural similarity with the extracellular matrix (ECM). The addition of active ingredients as a model drug helps accelerate wound healing through antimicrobial and antioxidant mechanisms. Three-dimensional (3D) bioprinting technology can print cellulose as a bioink to produce wound dressings with complex structures mimicking ECM. The 3D printed cellulose-based wound dressings are a promising application in modern wound care. This article reviews the use of 3D printed cellulose as an ideal wound dressing and their properties, including mechanical properties, permeability aspect, absorption ability, ability to retain and provide moisture, biodegradation, antimicrobial property, and biocompatibility. The applications of 3D printed cellulose in the management of chronic wounds, burns, and painful wounds are also discussed.
伤口是由创伤导致的皮肤组织损伤。许多因素会抑制伤口愈合阶段（止血、炎症、增殖和改建），如氧合作用、污染/感染、年龄、损伤影响、性激素、压力、糖尿病、肥胖、药物、酗酒、吸烟、营养、止血、清创和闭合时间。纤维素是自然界中最丰富的生物聚合物，因其良好的结构和机械稳定性，有望成为伤口敷料的主要基质，它能使伤口周围区域保持湿润，吸收多余的渗出液，可形成具有生物响应性、生物相容性、低毒性、可生物降解性以及与细胞外基质（ECM）结构相似性等特性的弹性凝胶。添加作为模型药物的活性成分有助于通过抗菌和抗氧化机制加速伤口愈合。三维（3D）生物打印技术可以将纤维素打印成生物墨水，以生产出具有模仿ECM复杂结构的伤口敷料。3D打印的纤维素基伤口敷料在现代伤口护理中具有广阔的应用前景。本文综述了3D打印纤维素作为理想伤口敷料的用途及其特性，包括机械性能、渗透性、吸收能力、保持和提供水分的能力、生物降解性、抗菌性能和生物相容性。还讨论了3D打印纤维素在慢性伤口、烧伤和疼痛伤口处理中的应用。
