Wang Lei, Verschuuren Erik A M, Paap Davy, Rondaan Christien, Raveling-Eelsing Elisabeth, Liu Siqi, Westra Johanna, Bos Nicolaas A
University Medical Center Groningen, Department of Rheumatology and Clinical Immunology, University of Groningen, 9713 EZ Groningen, The Netherlands.
University Medical Center Groningen, Department of Pulmonary Diseases and Tuberculosis, University of Groningen, 9713 EZ Groningen, The Netherlands.
Vaccines (Basel). 2021 Feb 28;9(3):202. doi: 10.3390/vaccines9030202.
The mean age of lung transplant recipients has significantly increased in recent decades. Elderly recipients have a higher risk of developing herpes zoster (HZ), and they have in general a worse response to vaccination than younger persons do. We investigated the relationship between the humoral and cellular immune response to a live-attenuated HZ vaccine (Zostavax, Merck Sharp and Dohme) and the frequencies of T and B cell subsets, especially aged cell subsets (CD28-T cells and age associated B cells, ABCs). In total, 37 patients awaiting lung transplantation received one dose of Zostavax, and peripheral blood was collected before and within 6 months after vaccination. We observed a robust immune response after vaccination. The frequencies of CD28-T cells before vaccination had no impact on the subsequent immune response to HZ vaccination. However, a higher frequency of ABCs before vaccination correlated with a lower immune response especially regarding the cellular immune response. Cytomegalovirus seropositivity was associated with increased frequencies of CD28-T cells but not with frequencies of ABCs in the patients. In conclusion, increased levels of ABCs might disturb the cellular immune response to HZ vaccination, which could lower the efficacy of such vaccination in elderly transplant recipients.
近几十年来，肺移植受者的平均年龄显著增加。老年受者发生带状疱疹（HZ）的风险更高，而且总体上他们对疫苗接种的反应比年轻人更差。我们研究了对减毒活HZ疫苗（默克公司的Zostavax）的体液免疫和细胞免疫反应与T细胞和B细胞亚群频率之间的关系，特别是衰老细胞亚群（CD28-T细胞和年龄相关B细胞，ABCs）。共有37名等待肺移植的患者接种了一剂Zostavax，并在接种前和接种后6个月内采集外周血。我们观察到接种疫苗后有强烈的免疫反应。接种前CD28-T细胞的频率对随后对HZ疫苗接种的免疫反应没有影响。然而，接种前较高频率的ABCs与较低的免疫反应相关，尤其是在细胞免疫反应方面。巨细胞病毒血清阳性与患者中CD28-T细胞频率增加有关，但与ABCs频率无关。总之，ABCs水平升高可能会干扰对HZ疫苗接种的细胞免疫反应，这可能会降低这种疫苗接种在老年移植受者中的疗效。
