Ford Bart N, Savitz Jonathan
Department of Pharmacology & Physiology, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA.
Laureate Institute for Brain Research, Tulsa, OK, USA.
Immun Ageing. 2022 Jul 14;19(1):32. doi: 10.1186/s12979-022-00288-7.
The aging process can have detrimental effects on the immune system rendering the elderly more susceptible to infectious disease and less responsive to vaccination. Major depressive disorder (MDD) has been hypothesized to show characteristics of accelerated biological aging. This raises the possibility that depressed individuals will show some overlap with elderly populations with respect to their immune response to infection and vaccination. Here we provide an umbrella review of this literature in the context of the SARS CoV-2 pandemic. On balance, the available data do indeed suggest that depression is a risk factor for both adverse outcomes following COVID-19 infection and for reduced COVID-19 vaccine immunogenicity. We conclude that MDD (and other major psychiatric disorders) should be recognized as vulnerable populations that receive priority for vaccination along with other at-risk groups.
衰老过程会对免疫系统产生不利影响，使老年人更容易感染传染病，且对疫苗接种的反应性降低。据推测，重度抑郁症（MDD）具有加速生物衰老的特征。这增加了一种可能性，即抑郁症患者在对感染和疫苗接种的免疫反应方面，会与老年人群体存在一些重叠。在此，我们在新冠病毒大流行的背景下，对这一文献进行综合综述。总体而言，现有数据确实表明，抑郁症是新冠病毒感染后出现不良后果以及新冠疫苗免疫原性降低的一个风险因素。我们得出结论，重度抑郁症（以及其他主要精神疾病）应被视为弱势群体，与其他高危群体一起优先接种疫苗。
