流感疫苗接种后的抗体反应减弱的特征是，与年龄相关的 B 细胞群体扩增，其 PAX5 水平较低。
Diminished antibody response to influenza vaccination is characterized by expansion of an age-associated B-cell population with low PAX5.
机构信息
Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, USA.
Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, AZ, USA.
出版信息
Clin Immunol. 2018 Aug;193:80-87. doi: 10.1016/j.clim.2018.02.003. Epub 2018 Feb 6.
Individuals over the age of 65 comprise a substantial portion of the world population and become more susceptible to vaccine-preventable infections with age as vaccination response diminishes. The underlying reason for this impaired vaccine response in older individuals is not entirely clear. We evaluated potential differences in phenotypic and functional responses of B cells from healthy younger (22-45years) and older (64-95years) individuals that may associate with a diminished antibody response to influenza vaccination. We report that age is associated with expansion of atypical memory B cells (CD10CD20CD21CD27) and an age-associated B cell (ABC, CD21T-betCD11c) phenotype. Reduced expression of PAX5 was also seen in older individuals. Poor influenza-specific antibody production following vaccination was associated with low PAX5 expression and a distinct composition of the ABC compartment. Collectively, these findings demonstrate that the characteristics of the ABC populations of older individuals are associated with antibody production following influenza vaccination.
年龄在 65 岁以上的个体在世界人口中占相当大的比例，随着年龄的增长，疫苗接种反应减弱，他们更容易感染可通过疫苗预防的感染。老年人疫苗反应受损的根本原因尚不完全清楚。我们评估了来自健康的年轻个体（22-45 岁）和老年个体（64-95 岁）的 B 细胞表型和功能反应的潜在差异，这些差异可能与流感疫苗接种后抗体反应减弱有关。我们报告称，年龄与非典型记忆 B 细胞（CD10CD20CD21CD27）的扩增和与年龄相关的 B 细胞（ABC，CD21T-betCD11c）表型有关。老年人的 PAX5 表达也减少。接种疫苗后产生的流感特异性抗体较差与低 PAX5 表达和 ABC 隔室的独特组成有关。综上所述，这些发现表明，老年人 ABC 群体的特征与流感疫苗接种后的抗体产生有关。
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