Butler W J, Hawthorne V M, Mikkelsen W M, Carman W J, Bouthillier D L, Lamphiear D E, Kazi I U
Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor 48109.
J Clin Epidemiol. 1988;41(5):467-73. doi: 10.1016/0895-4356(88)90048-0.
Radiographs of the fingers and wrists of adult participants in the Tecumseh Community Health Study in 1962-65 were examined for signs of osteoarthritis (OA). The severity of OA for each of 32 joints of the fingers and wrists was recorded for each individual. Attention was restricted to the 3035 participants who were 32 years of age or older and for whom a diagnosis of OA was available for each of 32 joints. Joint-specific prevalence rates of OA increased sharply with age for both sexes, and at the older ages, the prevalence rates for most joints were higher for females. Older individuals with OA also had a greater number of affected joints, with females having a greater number of affected joints than males. Of those individuals aged 44 years or younger, only 6.2% had one or more joints affected with OA. The percentages were 21.6 and 42.0% for those aged 45-59 years and 60 or more years, respectively. The distal interphalangeal (DIP) joints were the most frequently affected joints in all age categories for both sexes and OA in the proximal interphalangeal (PIP) joints was positively associated with OA in the DIP joints. However, controlling for the number of affected DIP joints, the PIP joints of older subjects were more likely to exhibit OA than the PIP joints of younger subjects. Though there is an association between OA in the DIP and PIP joints, there was only a small, nonsignificant association (OR = 1.24, 95% CI = 0.83, 1.84) between disease in the DIP and PIP joints of the same finger.
1962年至1965年参加蒂卡姆西社区健康研究的成年参与者的手指和手腕X光片被检查是否有骨关节炎(OA)迹象。记录了每个个体手指和手腕32个关节中每个关节的OA严重程度。研究对象仅限于3035名年龄在32岁及以上且每个32个关节都有OA诊断结果的参与者。男女两性的关节特异性OA患病率均随年龄急剧上升,在较高年龄段,大多数关节的患病率女性高于男性。患有OA的老年人受影响的关节数量也更多,女性受影响的关节数量比男性多。在44岁及以下的个体中,只有6.2%的人有一个或多个关节受OA影响。45至59岁和60岁及以上人群的这一比例分别为21.6%和42.0%。在所有年龄组中,男女的远端指间(DIP)关节都是最常受影响的关节,近端指间(PIP)关节的OA与DIP关节的OA呈正相关。然而,在控制受影响的DIP关节数量后,老年受试者的PIP关节比年轻受试者的PIP关节更易出现OA。虽然DIP和PIP关节的OA之间存在关联,但同一手指的DIP和PIP关节疾病之间只有很小的、无统计学意义的关联(OR = 1.24,95% CI = 0.83,1.84)。