Tumor Immunology and Immunotherapy Unit, IRCCS Regina Elena National Cancer Institute, via Chianesi 53, 00144 Rome, Italy.
Institute of Biochemistry and Cell Biology, National Research Council, via Ramarini 32, 00015 Monterotondo Scalo, Rome, Italy.
Biomolecules. 2021 Feb 23;11(2):336. doi: 10.3390/biom11020336.
Human tissues, to maintain their architecture and function, respond to injuries by activating intricate biochemical and physical mechanisms that regulates intercellular communication crucial in maintaining tissue homeostasis. Coordination of the communication occurs through the activity of different actin cytoskeletal regulators, physically connected to extracellular matrix through integrins, generating a platform of biochemical and biomechanical signaling that is deregulated in cancer. Among the major pathways, a controller of cellular functions is the cytokine transforming growth factor β (TGFβ), which remains a complex and central signaling network still to be interpreted and explained in cancer progression. Here, we discuss the link between actin dynamics and TGFβ signaling with the aim of exploring their aberrant interaction in cancer.
为了维持组织结构和功能，人体组织会在受到损伤时激活复杂的生化和物理机制，调节细胞间通讯，这对维持组织稳态至关重要。这种通讯的协调是通过不同的肌动蛋白细胞骨架调节剂的活性来实现的，这些调节剂通过整合素与细胞外基质物理连接，形成一个生化和生物力学信号的平台，而这个平台在癌症中是失调的。在主要途径中，细胞功能的控制器是细胞因子转化生长因子 β（TGFβ），它仍然是一个复杂且核心的信号网络，在癌症进展中仍有待解释和阐明。在这里，我们讨论了肌动蛋白动力学与 TGFβ 信号之间的联系，旨在探索它们在癌症中的异常相互作用。
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