Univ. Bordeaux, INSERM UMR 1219, Equipe EPICENE, F33000 Bordeaux, France.
CHU de Bordeaux, Service Santé Travail Environnement, F33000 Bordeaux, France.
Int J Environ Res Public Health. 2021 Feb 23;18(4):2200. doi: 10.3390/ijerph18042200.
Active tobacco exposure during pregnancy is a known determinant of fetal growth. Nitrates and atrazine metabolites in drinking water may affect fetal growth as a mixture of endocrine disruptors (ED). We aimed to determine whether EDC have an additional effect on fetal growth compared to active tobacco exposure. A historic cohort study was carried out with a sample stratified with regard to the maternity unit, drinking water exposure, and year of birth. The women included were living in Deux-Sèvres, had given birth between 2005 and 2010 in three selected maternity units, and ultrasound data were available in their obstetrical records. Mixed linear models were used to analyze fetal weight evolution from the second trimester to the time of birth according to drinking water exposure to EDC mixture and active tobacco exposure. We included 558 mother-neonate couples, of whom 9% were exposed to high doses of the mixture and 21% to active tobacco smoking. There was no difference in fetal weight evolution according to drinking water mixture exposure (0.97 g; 95% CI [-3.01; 4.94]). We could not show a supplementary effect of mixture exposure in drinking-water on fetal growth as compared to active tobacco exposure. Further research is needed, using more precise methods to estimate EDC exposure.
孕期主动吸烟暴露是胎儿生长的已知决定因素。饮用水中的硝酸盐和莠去津代谢物可能会对胎儿生长产生影响，因为它们是内分泌干扰物 (ED) 的混合物。我们旨在确定与主动吸烟暴露相比，EDC 是否对胎儿生长有额外影响。这项历史性队列研究是在样本分层的基础上进行的，分层因素包括产科病房、饮用水暴露和出生年份。纳入的妇女居住在 Deux-Sèvres，在三个选定的产科病房分娩，分娩时间在 2005 年至 2010 年之间，其产科记录中都有超声数据。根据饮用水中 EDC 混合物和主动吸烟暴露情况，采用混合线性模型分析胎儿体重从妊娠中期到出生时的变化情况。我们纳入了 558 对母婴，其中 9%暴露于混合物的高剂量，21%暴露于主动吸烟。饮用水混合物暴露与胎儿体重变化无差异（0.97 克；95%CI[-3.01；4.94]）。与主动吸烟暴露相比，我们不能证明饮用水中混合物暴露对胎儿生长有额外的影响。需要进一步研究，使用更精确的方法来估计 EDC 暴露。
