Department of Medicine, Biomedical Campus, University of Cambridge, Cambridge CB2 0AW, UK.
Viruses. 2021 Feb 20;13(2):324. doi: 10.3390/v13020324.
Viruses are obligate parasites that rely on host cellular factors to replicate and spread. The endosomal sorting complexes required for transport (ESCRT) system, which is classically associated with sorting and downgrading surface proteins, is one of the host machineries hijacked by viruses across diverse families. Knowledge gained from research into ESCRT and viruses has, in turn, greatly advanced our understanding of many other cellular functions in which the ESCRT pathway is involved, e.g., cytokinesis. This review highlights the interplay between the ESCRT pathway and the viral factors of enveloped viruses with a special emphasis on retroviruses.
病毒是专性寄生的，它们依赖宿主细胞因子来复制和传播。内体分选复合物需要运输（ESCRT）系统，该系统与表面蛋白的分选和降级有关，是被不同病毒家族劫持的宿主机制之一。对 ESCRT 和病毒的研究反过来极大地促进了我们对 ESCRT 途径参与的许多其他细胞功能的理解，例如胞质分裂。本综述强调了 ESCRT 途径与包膜病毒的病毒因子之间的相互作用，特别强调了逆转录病毒。
