Wohlmuth Christoph, Wohlmuth-Wieser Iris
Department of Obstetrics and Gynecology, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.
Department of Dermatology, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.
J Clin Med. 2021 Feb 12;10(4):722. doi: 10.3390/jcm10040722.
The aim of this study is to assess the projected incidence and prognostic indicators of gynecologic malignancies in the pediatric population. In this population-based retrospective cohort study, girls ≤18 years with ovarian, uterine, cervical, vaginal and vulvar malignancies diagnosed between 2000 and 2016 were identified from the Surveillance, Epidemiology and End Results (SEER)-18 registry. The Kaplan-Meier method was used to analyze overall survival (OS). The age-adjusted annual incidence of gynecologic malignancies was 6.7 per 1,000,000 females, with neoplasms of the ovary accounting for 87.5%, vagina 4.5%, cervix 3.9%, uterus 2.5% and vulva 1.6% of all gynecologic malignancies. Malignant germ-cell tumors represented the most common ovarian neoplasm, with an increased incidence in children from 5-18 years. Although certain subtypes were associated with advanced disease stages, the 10-year OS rate was 96.0%. Sarcomas accounted for the majority of vaginal, cervical, uterine and vulvar malignancies. The majority of vaginal neoplasms were observed in girls between 0-4 years, and the 10-year OS rate was 86.1%. Overall, gynecologic malignancies accounted for 4.2% of all malignancies in girls aged 0-18 years and the histologic subtypes and prognosis differed significantly from patients in older age groups.
本研究的目的是评估儿科人群中妇科恶性肿瘤的预计发病率和预后指标。在这项基于人群的回顾性队列研究中，从监测、流行病学和最终结果（SEER）-18登记处识别出2000年至2016年间诊断为卵巢、子宫、宫颈、阴道和外阴恶性肿瘤的18岁及以下女孩。采用Kaplan-Meier方法分析总生存期（OS）。妇科恶性肿瘤的年龄调整年发病率为每100万女性6.7例，其中卵巢肿瘤占所有妇科恶性肿瘤的87.5%，阴道肿瘤占4.5%，宫颈肿瘤占3.9%，子宫肿瘤占2.5%，外阴肿瘤占1.6%。恶性生殖细胞肿瘤是最常见的卵巢肿瘤，5至18岁儿童的发病率有所增加。尽管某些亚型与疾病晚期相关，但10年总生存率为96.0%。肉瘤占阴道、宫颈、子宫和外阴恶性肿瘤的大多数。大多数阴道肿瘤在0至4岁的女孩中观察到，10年总生存率为86.1%。总体而言，妇科恶性肿瘤占0至18岁女孩所有恶性肿瘤的4.2%，其组织学亚型和预后与老年患者有显著差异。
