Yuan H C, Yu Q T, Bai H, Xu H Z, Gu P, Chen L Y
Department of Nutrition, Qingdao Municipal Hospital, Qingdao, China.
The People's Hospital of Huaiyin, Jinan, China.
Eur J Clin Nutr. 2021 Nov;75(11):1555-1567. doi: 10.1038/s41430-021-00873-x. Epub 2021 Mar 5.
Many prospective cohort studies have investigated the association between the consumption of alcohol and CKD risk and have revealed inconsistent results. In the present study, we aimed to perform a meta-analysis of these studies to assess this association.We searched the PubMed and Embase databases up to 2020 and reviewed the reference lists of relevant articles to identify appropriate studies. We calculated the pooled relative risks with 95% CIs using random effects models, and then performed subgroup and meta-regression analyses. Dose-response meta-analyses were performed by sex separately. We identified 25 eligible prospective cohort studies, including 514,148 participants and 35,585 incident CKD cases. Compared with the category of minimal alcohol intake, light (RR = 0.90, I2 = 49%), moderate (RR = 0.86, I2 = 40%), and heavy (RR = 0.85, I2 = 51%) alcohol intake were associated with a lower risk of CKD. Subgroup meta-analysis by sex indicated that light (RR = 0.92, I2 = 0%), moderate (RR = 0.83, I2 = 39%) and heavy (RR = 0.76, I2 = 40%), alcohol consumption were inversely associated with CKD risk in male. Dose-response meta-analyses detected a nonlinear inverse association between alcohol consumption and the risk of CKD in all participants and linear inverse association in female participants. This meta-analysis shows that light (<12 g/day), moderate (12-24 g/day), and heavy (>24 g/day) alcohol consumption are protective against chronic kidney disease in adult participants especially in males.
许多前瞻性队列研究调查了饮酒与慢性肾脏病（CKD）风险之间的关联，结果并不一致。在本研究中，我们旨在对这些研究进行荟萃分析，以评估这种关联。我们检索了截至2020年的PubMed和Embase数据库，并查阅了相关文章的参考文献列表，以确定合适的研究。我们使用随机效应模型计算了合并相对风险及95%置信区间，然后进行亚组分析和meta回归分析。按性别分别进行剂量反应荟萃分析。我们确定了25项符合条件的前瞻性队列研究，包括514148名参与者和35585例新发CKD病例。与最低酒精摄入量组相比，轻度（RR = 0.90，I² = 49%）、中度（RR = 0.86，I² = 40%）和重度（RR = 0.85，I² = 51%）酒精摄入与较低的CKD风险相关。按性别进行的亚组荟萃分析表明，轻度（RR = 0.92，I² = 0%）、中度（RR = 0.83，I² = 39%）和重度（RR = 0.76，I² = 40%）酒精消费与男性CKD风险呈负相关。剂量反应荟萃分析在所有参与者中检测到酒精消费与CKD风险之间存在非线性负相关，在女性参与者中存在线性负相关。这项荟萃分析表明，轻度（<12克/天）、中度（12 - 24克/天）和重度（>24克/天）酒精消费对成年参与者尤其是男性的慢性肾脏病具有保护作用。
