Peng Lihong, Fu Chenying, Wang Lu, Zhang Qing, Liang Zejun, He Chengqi, Wei Quan
Department of Rehabilitation Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Key Laboratory of Rehabilitation Medicine in Sichuan, Chengdu, Sichuan, China.
Bioelectromagnetics. 2021 Apr;42(3):250-258. doi: 10.1002/bem.22330. Epub 2021 Mar 6.
A pulsed electromagnetic field (PEMF) has been used to treat inflammation-based diseases such as osteoporosis, neurological injury, and osteoarthritis. Numerous animal experiments and in vitro studies have shown that PEMF may affect angiogenesis. For ischemic diseases, in theory, blood flow may be richer by increasing the number of blood vessels which supply blood to ischemic tissue. PEMF plays a role in enhancing angiogenesis, and their clinical application may go far beyond the current scope. In this review, we analyzed and summarized the effects and possible mechanisms of PEMF on angiogenesis. Most studies have shown that PEMF with specific parameters can promote angiogenesis, which is manifested by an increased vascular growth rate and increased capillary density. The potential mechanisms consist of promoting vascular endothelial cell proliferation, migration, and tube formation, and increasing the expression level of vascular endothelial growth factor (VEGF), fibroblast growth factor 2 (FGF2), angiopoietin-2 (Ang-2), and other angiogenic growth factors. Additionally, PEMF has an impact on the activation of voltage-gated calcium channels (VGCC). Bioelectromagnetics. © 2021 Bioelectromagnetics Society.
脉冲电磁场（PEMF）已被用于治疗基于炎症的疾病，如骨质疏松症、神经损伤和骨关节炎。大量动物实验和体外研究表明，PEMF可能影响血管生成。对于缺血性疾病，理论上，通过增加向缺血组织供血的血管数量，血流量可能会更丰富。PEMF在增强血管生成中发挥作用，其临床应用可能远远超出当前范围。在本综述中，我们分析并总结了PEMF对血管生成的影响及可能机制。大多数研究表明，具有特定参数的PEMF可促进血管生成，表现为血管生长速率增加和毛细血管密度增加。潜在机制包括促进血管内皮细胞增殖、迁移和管腔形成，以及增加血管内皮生长因子（VEGF）、成纤维细胞生长因子2（FGF2）、血管生成素-2（Ang-2）和其他血管生成生长因子的表达水平。此外，PEMF对电压门控钙通道（VGCC）的激活有影响。生物电磁学。©2021生物电磁学会。
