Zhang Anao, Wang Kaipeng, Zebrack Bradley, Tan Chiu Yi, Walling Emily, Chugh Rashmi
University of Michigan School of Social Work, United States.
University of Denver Graduate School of Social Work, United States.
Crit Rev Oncol Hematol. 2021 Apr;160:103291. doi: 10.1016/j.critrevonc.2021.103291. Epub 2021 Mar 3.
Pediatric, adolescent, and young adult (PAYA) cancer survivors suffer from multiple domains of adverse psychosocial and behavioral outcomes during and after their cancer treatment. This study conducted a systematic review and metaanalysis of psychosocial, behavioral, and supportive interventions for PAYA cancer survivors.
We searched 11 electronic databases, 4 professional websites, and manual search of reference lists in existing reviews. We selected randomized controlled trials and controlled trials without randomization focusing on PAYA cancer survivors across six outcome domains.
We included 61 studies (4,402 participants) published between 1987 and 2020. Overall risk of bias across studies was low. We identified an overall moderate and statistically significant treatment effect size for PAYA cancer survivors across six outcome domains.
psychosocial, behavioral, and supportive interventions were overall effective for PAYA cancer survivors. However, interventions were not effective for certain outcome domains, and less effective among AYA versus pediatric cancer survivors.
儿童、青少年和青年（PAYA）癌症幸存者在癌症治疗期间及之后会遭受多个领域的不良心理社会和行为后果。本研究对PAYA癌症幸存者的心理社会、行为和支持性干预措施进行了系统评价和荟萃分析。
我们检索了11个电子数据库、4个专业网站，并手动检索了现有综述中的参考文献列表。我们选择了针对PAYA癌症幸存者、聚焦六个结局领域的随机对照试验和非随机对照试验。
我们纳入了1987年至2020年间发表的61项研究（4402名参与者）。各研究的总体偏倚风险较低。我们确定了PAYA癌症幸存者在六个结局领域的总体中度且具有统计学意义的治疗效应大小。
心理社会、行为和支持性干预措施总体上对PAYA癌症幸存者有效。然而，干预措施对某些结局领域无效，且在青年与儿童癌症幸存者中效果较差。
