Department of Population Health & Disease Prevention, Joe C. Wen School of Population & Public Health, University of California, 856 Health Sciences Drive, Irvine, CA, 92697-3957, USA.
Chao Family Comprehensive Cancer Center, University of California, Irvine, USA.
Support Care Cancer. 2024 Oct 30;32(11):758. doi: 10.1007/s00520-024-08960-y.
Young adult Latino testicular cancer survivors experience adverse impacts after treatment. We developed Goal-focused Emotion regulation Therapy (GET) to improve distress symptoms, goal navigation skills, and emotion regulation. This open pilot trial extended GET to Latino young adult survivors of testicular cancer and assessed feasibility and tolerability as well as changes in anxiety and depressive symptoms. Secondary outcomes included goal navigation, emotion regulation, and components of hope-related goal processes (i.e., agency and pathway mapping). To assess the extent to which GET is culturally congruent or in need of adaptation, the influence of simpatía and acculturative stress were also examined.
Thirty-five eligible young adult (age 18-39) survivors treated with chemotherapy were enrolled and assessed at baseline. Study acceptability, tolerability, and therapeutic alliance were examined. Preliminary efficacy was evaluated for changes in anxiety and depressive symptoms as well as psychological processes (goal navigation, agency, goal pathway skill, and emotion regulation) from baseline to immediate post- and 3-month post-intervention.
Among the 35 men assessed at baseline, 54% initiated intervention sessions. Among these, 94.7% completed all study procedures. Helpfulness ratings of intervention components and therapeutic alliance scores were strong. Repeated measures ANOVA revealed significant reductions in anxiety and depressive symptoms from pre- to post-intervention with sustained change at the 3-month follow-up. Favorable patterns of change were also observed in GET-related psychological processes. Simpatía was associated with less depressive symptoms at post-intervention, but not change in anxiety. Acculturative stress was associated with increased anxiety and depressive symptoms over time.
GET is a feasible and acceptable intervention for reducing adverse outcomes after testicular cancer for young adult Latino men. Results should be considered preliminary but suggest meaningful changes in emotional and psychological outcomes.
年轻的拉丁裔睾丸癌幸存者在治疗后会经历不良影响。我们开发了以目标为导向的情绪调节疗法（GET），以改善困扰症状、目标导航技能和情绪调节。这项开放的试点试验将 GET 扩展到拉丁裔睾丸癌年轻幸存者，并评估了可行性和耐受性，以及焦虑和抑郁症状的变化。次要结果包括目标导航、情绪调节和与希望相关的目标过程的组成部分（即能动性和途径映射）。为了评估 GET 在多大程度上具有文化一致性或需要适应，还检查了 simpatía 和文化适应压力的影响。
招募并评估了 35 名符合条件的接受过化疗的 18-39 岁年轻幸存者。研究可接受性、耐受性和治疗联盟进行了检查。初步评估了焦虑和抑郁症状以及心理过程（目标导航、能动性、目标途径技能和情绪调节）从基线到即时后和 3 个月后的变化，以评估干预的初步疗效。
在基线评估的 35 名男性中，有 54%开始接受干预。在这些人中，有 94.7%完成了所有研究程序。干预组件的有用性评分和治疗联盟评分都很强。重复测量方差分析显示，从干预前到干预后，焦虑和抑郁症状显著减轻，在 3 个月随访时持续改善。在与 GET 相关的心理过程中也观察到了有利的变化模式。在干预后，simpatía 与抑郁症状减少相关，但与焦虑变化无关。文化适应压力与焦虑和抑郁症状随时间的增加有关。
GET 是一种针对年轻拉丁裔男性睾丸癌后减少不良后果的可行且可接受的干预措施。结果应被视为初步的，但表明在情绪和心理结果方面有了有意义的变化。
