中国郑州的大气污染物暴露与体外受精治疗结局。
Ambient air pollutant exposure and in vitro fertilization treatment outcomes in Zhengzhou, China.
机构信息
Reproductive Medical Center, Henan Province Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052 Henan, China.
出版信息
Ecotoxicol Environ Saf. 2021 May;214:112060. doi: 10.1016/j.ecoenv.2021.112060. Epub 2021 Mar 3.
OBJECTIVE
To study the association between ambient air pollutant exposure during the follicular phase and in vitro fertilization (IVF) outcomes.
DESIGN
A single-center retrospective analysis.
SETTING
Henan Province, China.
PATIENTS
Patients (n = 6659) living in Zhengzhou, Henan Province in central China who underwent their first IVF cycle at the First Affiliated Hospital of Zhengzhou University between 2013 and 2019 were included for analysis.
INTERVENTION
None.
MAIN OUTCOME MEASURE
The relationships between PM, PM, and AQI (Air Quality Index) with IVF outcomes during the follicular phase (period I, 85 days before oocyte retrieval; period II, gonadotrophin start to oocyte retrieval).
RESULTS
Compared with the bottom tertile, exposure to the top PM and PM tertiles during period I was associated with decreased clinical pregnancy (PM: adjusted odds ratio [OR], 0.838%, and 95% confidence interval [CI], 0.723 and 0.971; PM: adjusted OR, 0.818%, and 95% CI, 0.705 and 0.950), and decreased live birth rate (PM: adjusted odds ratio [OR], 0.852%, and 95% confidence interval [CI], 0.736 and 0.987; PM: adjusted OR, 0.850%, and 95% CI, 0.733 and 0.986), and exposure to the top PM tertile during period II adversely affected clinical pregnancy and the live birth rate (adjusted OR, 0.824%, and 95% CI, 0.711 and 0.955; adjusted OR, 0.817%, and 95% CI, 0.706 and 0.945). Compared with the bottom PM tertile, exposure to the middle PM tertile in period II showed decreased clinical pregnancies and live births (adjusted OR, 0.844; 95% CI, 0.729 and 0.978, adjusted OR, 0.846; 95% CI, 0.731 and 0.979). The PM level during period II of the follicular phase tend to adversely affect live birth rate, but the tendency did not reach significance (P = 0.051).
CONCLUSION
Exposure to PM and PM before oocyte retrieval has an adverse effect on IVF outcomes.
CAPSULE
Exposure to PM and PM before oocyte retrieval has an adverse effect on IVF outcomes.
目的
研究卵泡期暴露于环境空气污染物与体外受精（IVF）结局之间的关系。
设计
单中心回顾性分析。
地点
中国河南省。
患者
纳入 2013 年至 2019 年期间在郑州大学第一附属医院进行首次 IVF 周期的 6659 名居住在中国中部河南省郑州市的患者进行分析。
干预
无。
主要观察指标
卵泡期（周期 I，取卵前 85 天；周期 II，开始使用促性腺激素至取卵）期间 PM、PM 和 AQI（空气质量指数）与 IVF 结局的关系。
结果
与最低三分位相比，周期 I 中处于 PM 和 PM 最高三分位的暴露与临床妊娠率降低相关（PM：调整后的优势比[OR]，0.838%，95%置信区间[CI]，0.723 和 0.971；PM：调整后的 OR，0.818%，95%CI，0.705 和 0.950），活产率降低（PM：调整后的优势比[OR]，0.852%，95%置信区间[CI]，0.736 和 0.987；PM：调整后的 OR，0.850%，95%CI，0.733 和 0.986），周期 II 中 PM 最高三分位的暴露也对临床妊娠和活产率产生不利影响（调整后的 OR，0.824%，95%CI，0.711 和 0.955；调整后的 OR，0.817%，95%CI，0.706 和 0.945）。与最低 PM 三分位相比，周期 II 中处于中间 PM 三分位的暴露显示临床妊娠和活产率降低（调整后的 OR，0.844；95%CI，0.729 和 0.978，调整后的 OR，0.846；95%CI，0.731 和 0.979）。卵泡期周期 II 期间的 PM 水平可能对活产率产生不利影响，但这种趋势没有达到显著水平（P=0.051）。
结论
取卵前暴露于 PM 和 PM 对 IVF 结局有不良影响。
胶囊总结
取卵前暴露于 PM 和 PM 对 IVF 结局有不良影响。
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