Grenhoff J, Svensson T H
Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Life Sci. 1988;42(20):2003-9. doi: 10.1016/0024-3205(88)90500-0.
The effects of clonidine on the activity of single substantia nigra dopamine neurons were studied in the chloral hydrate anesthetized rat. Although clonidine did not affect the firing rate of the cells, it regularized the firing pattern and decreased burst firing at 2-8 micrograms kg-1 i.v. These effects were antagonized by the alpha 2-antagonist yohimbine. Yohimbine (1.0 mg kg-1) deregularized the firing pattern and increased the firing rate as well as the burst firing. The regularization produced by clonidine is discussed in terms of synaptic efficacy. The results might explain the therapeutic effects of clonidine in certain neuropsychiatric disorders.
在水合氯醛麻醉的大鼠中研究了可乐定对单个黑质多巴胺能神经元活性的影响。尽管可乐定不影响细胞的放电频率，但在静脉注射2 - 8微克/千克时，它使放电模式正常化并减少爆发式放电。这些效应被α2拮抗剂育亨宾所拮抗。育亨宾（1.0毫克/千克）使放电模式紊乱，增加了放电频率以及爆发式放电。从突触效能方面讨论了可乐定产生的正常化作用。这些结果可能解释了可乐定在某些神经精神疾病中的治疗作用。
