Dynamic Omics, Antibody Discovery and Protein Engineering, R&D AstraZeneca, Gaithersburg, MD 20878, USA.
Microbial Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD 20878, USA.
Int J Biochem Cell Biol. 2021 May;134:105966. doi: 10.1016/j.biocel.2021.105966. Epub 2021 Mar 5.
As we learn more about chronic lung diseases, we are seeing that an unbalanced immune system plays a key role in disease pathogenesis. Innate immune cells, particularly tissue-resident macrophages, are important navigators of immunity, both during infection and in non-communicable lung disease. In the lung, alveolar macrophages are considered some of the most critical and diverse immune cells, yet despite an array of studies over the years, alveolar macrophages remain poorly understood. In this review, we highlight the importance of alveolar macrophages in health and disease, and discuss how proteomics can be used to elucidate mechanistic information and identify potential targets for therapy development.
随着我们对慢性肺部疾病了解的深入，我们发现失衡的免疫系统在疾病发病机制中起着关键作用。先天免疫细胞，特别是组织驻留的巨噬细胞，在感染和非传染性肺部疾病期间都是免疫的重要导航者。在肺部，肺泡巨噬细胞被认为是最关键和最多样化的免疫细胞之一，但尽管多年来进行了大量研究，肺泡巨噬细胞仍然知之甚少。在这篇综述中，我们强调了肺泡巨噬细胞在健康和疾病中的重要性，并讨论了蛋白质组学如何用于阐明机制信息和确定治疗开发的潜在靶点。
